INT154515

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.17
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Ephb2) kinase activity (Ephb2)
Anatomy Link Frequency
Spinal 1
Ephb2 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 168 98.72 Very High Very High Very High
Spinal cord 61 98.20 Very High Very High Very High
Morphine 5 97.80 Very High Very High Very High
withdrawal 3 97.44 Very High Very High Very High
Physical dependence 3 96.56 Very High Very High Very High
Calcitonin gene-related peptide 1 94.96 High High
spinal dorsal horn 101 86.72 High High
addiction 2 86.72 High High
c fibre 56 86.32 High High
tolerance 1 86.12 High High
Disease Link Frequency Relevance Heat
Drug Dependence 3 96.56 Very High Very High Very High
Pain 14 34.64 Quite Low
Hyperalgesia 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal administration of an EphB receptor blocking reagent EphB2-Fc prevents and/or suppresses behavioral responses to morphine withdrawal and associated induction of c-Fos and depletion of calcitonin gene-related peptide.
Neg (blocking) Localization (blocking) of EphB2 in Spinal associated with withdrawal, calcitonin gene-related peptide and morphine
1) Confidence 0.73 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.17 Pain Relevance 1.03
The results showed that HFS-induced increases of p-CaMKII (10 min), p-ERK (10 min) and p-CREB (2 h) protein levels were partly, but significantly reduced by pretreatment of EphB2-Fc (2 ?
Localization (pretreatment) of EphB2
2) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.23
The results showed that LTP induced in WT mice (Fig. 5A) was successfully prevented by pre-application of a soluble EphB receptor blocker EphB2-Fc (2 ?
Localization (application) of EphB2 associated with long-term potentiation
3) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.51

General Comments

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