INT154516

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.24
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ephb6) plasma membrane (Ephb6)
Ephb6 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 61 99.44 Very High Very High Very High
Opioid 2 97.92 Very High Very High Very High
Physical dependence 3 97.64 Very High Very High Very High
withdrawal 3 96.68 Very High Very High Very High
long-term potentiation 168 94.56 High High
nMDA receptor 15 88.20 High High
Morphine 5 84.32 Quite High
spinal dorsal horn 101 82.84 Quite High
Glutamate receptor 8 81.76 Quite High
opiate 1 78.32 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 97.64 Very High Very High Very High
Hyperalgesia 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ephrinB-EphB interaction is well known to mediate bidirectional signals that propagate into EphB-expressing cells (forward signaling) and ephrinB-expression cells (reverse signaling).
EphB Binding (interaction) of
1) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.39
Recent studies have proposed mechanisms for potential interactions between ephrinB-EphB receptors and AMPA, NMDA and mGlu receptors [46-49].
EphB Binding (interactions) of
2) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.25
These findings indicate that EphB receptor signaling, probably by interacting with NR2B in SC, contributes to the development of opioid physical dependence and withdrawal effects.
EphB receptor Binding (interacting) of associated with physical dependence, withdrawal, opioid and spinal cord
3) Confidence 0.21 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.24 Pain Relevance 1.27

General Comments

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