INT154518

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ephb6, Grin2b) transport (Grin2b) extracellular region (Ephb6)
embryo development (Grin2b)
Ephb6 (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.84 Very High Very High Very High
Opioid 2 98.32 Very High Very High Very High
Physical dependence 3 98.04 Very High Very High Very High
withdrawal 3 97.08 Very High Very High Very High
nMDA receptor 1 88.20 High High
Morphine 5 84.32 Quite High
spinal dorsal horn 1 82.00 Quite High
opiate 1 79.12 Quite High
addiction 2 78.56 Quite High
Calcitonin gene-related peptide 1 75.56 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 98.04 Very High Very High Very High
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that EphB receptor signaling, probably by interacting with NR2B in SC, contributes to the development of opioid physical dependence and withdrawal effects.
EphB receptor Binding (interacting) of NR2B associated with physical dependence, withdrawal, opioid and spinal cord
1) Confidence 0.21 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.24 Pain Relevance 1.28

General Comments

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