INT154527

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 180
Total Number 184
Disease Relevance 34.01
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1)
DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)
Anatomy Link Frequency
endometrium 18
germ cells 18
stem cell 11
neural 4
fibroblasts 3
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 138 99.40 Very High Very High Very High
pain pelvic 92 98.96 Very High Very High Very High
Potency 230 98.80 Very High Very High Very High
Dismenorea 92 96.40 Very High Very High Very High
Hippocampus 150 95.32 Very High Very High Very High
ischemia 62 94.08 High High
Nicotine 79 90.96 High High
cytokine 490 90.16 High High
imagery 17 88.72 High High
Inflammation 922 88.60 High High
Disease Link Frequency Relevance Heat
Breast Cancer 63 99.86 Very High Very High Very High
Malignant Neoplastic Disease 141 99.84 Very High Very High Very High
Cancer 691 99.76 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 50 99.72 Very High Very High Very High
Endometriosis (extended) 236 99.68 Very High Very High Very High
Targeted Disruption 143 99.50 Very High Very High Very High
Severe Combined Immunodeficiency 106 99.40 Very High Very High Very High
Keloid Scars 1751 99.36 Very High Very High Very High
Reprotox - General 3 92 98.96 Very High Very High Very High
Obesity 330 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding does not support the concept of cyclical endometrial renewal based on hormonally modulated local OCT-4 expressing cells.
Gene_expression (expressing) of OCT-4
1) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.09 Pain Relevance 0
In a univariate regression model, the day of the menstrual cycle, using 3-day intervals, did not influence OCT-4 protein expression, when comparing an IRS <6 vs. ?
Gene_expression (expression) of OCT-4 protein
2) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.33 Pain Relevance 0.17
Figure 3 shows follicular and luteal phase endometrial samples with and without OCT-4 overexpression.
Gene_expression (overexpression) of OCT-4
3) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.27 Pain Relevance 0.14
Figure 2 demonstrates OCT-4 cDNA expression in endometrial samples of the follicular and luteal phases.
Gene_expression (expression) of OCT-4 cDNA
4) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.41 Pain Relevance 0.21
In the present study we assessed the mRNA levels and protein expression of OCT-4 in human endometrium.
Gene_expression (expression) of OCT-4 in endometrium
5) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
OCT-4 protein overexpression in the follicular and luteal phase was found in 33/49 (67%) and 23/40 (58%) of women, respectively (p = 0.5).
Gene_expression (overexpression) of OCT-4 protein
6) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.38 Pain Relevance 0.19
Increased mRNA levels and increased OCT-4 protein expression were significantly correlated (Pearson's correlation coefficient 0.8).
Gene_expression (expression) of OCT-4 protein
7) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.31 Pain Relevance 0.16
Our results compare with other studies in that OCT-4 has been demonstrated to be expressed in the human endometrium [12].
Gene_expression (expressed) of OCT-4 in endometrium
8) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
For example, the semiquantitative technique of immunohistochemistry and the small sample size may miss subtle differences in OCT-4 expression.
Gene_expression (expression) of OCT-4
9) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.08 Pain Relevance 0
We found that OCT-4 expression was restricted to the plasma of epithelial endometrium cells.
Gene_expression (expression) of OCT-4 in endometrium
10) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.27 Pain Relevance 0.14
Thus, we can only rule out a profound influence of menstrual cycle-dependent changes of the human endometrium on OCT-4 expression.
Gene_expression (expression) of OCT-4 in endometrium
11) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.13 Pain Relevance 0.03
We found that OCT-4 expression was restricted to the cytosol of epithelial endometrium cells.
Gene_expression (expression) of OCT-4 in endometrium
12) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.08 Pain Relevance 0
Thus, other yet unknown factors influencing the expression of OCT-4 may be present in human endometrium.
Gene_expression (expression) of OCT-4 in endometrium
13) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.13 Pain Relevance 0.03
OCT-4 protein overexpression was identified in 56/89 (63%) samples.
Gene_expression (overexpression) of OCT-4 protein
14) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.39 Pain Relevance 0.20
This rejects our study hypothesis that OCT-4 is overexpressed during endometrial proliferation in the follicular phase and downregulated during the secretory transformation of the endometrium in the luteal phase.
Gene_expression (overexpressed) of OCT-4 in endometrium associated with endometriosis (extended)
15) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.10 Pain Relevance 0
OCT-4, however, is not differentially expressed on the mRNA and protein levels during the menstrual cycle.
Neg (not) Gene_expression (expressed) of OCT-4
16) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
Consistently, our results showed that GF-iPS-3F cell clones highly expressed ES cell marker genes, including Nanog and endogenous Oct3/4.
Gene_expression (expressed) of Oct3
17) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
We evaluated the expression of Oct4 (POU5F1) to determine whether exogenic Oct4 induced the expression of early developmental genes KLF4, Sox-2, Rex-1, Utf1, Dapp5, FGF4, ERas, and Nanog in cultured ATSCs (Fig. 1E).
Gene_expression (expression) of Oct4
18) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.18 Pain Relevance 0.03
When Oct4 expression was recovered by exogenic Oct4 gene overexpression in damaged cells, ATSCs recovered to normal and viable cell with cell survival related signal pathway molecule such as Akt/PI3K, Bcl2, and ERK1/2.
Gene_expression (overexpression) of Oct4
19) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.28 Pain Relevance 0
We studied the effect of Oct4 overexpression on mesodermal lineage differentiation into fat, bone, and chondrocyte of ATSCs.
Gene_expression (overexpression) of Oct4 in fat
20) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox