INT154559

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Syk) plasma membrane (Syk) cytoplasm (Syk)
Anatomy Link Frequency
B-cell 1
spleen 1
Syk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 11 96.76 Very High Very High Very High
Inflammatory response 2 91.88 High High
Inflammation 24 77.44 Quite High
Arthritis 10 67.08 Quite High
cINOD 1 42.64 Quite Low
Bioavailability 4 35.48 Quite Low
dexamethasone 2 9.60 Low Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 6 99.00 Very High Very High Very High
INFLAMMATION 26 91.88 High High
Autoimmune Disease 12 83.60 Quite High
Arthritis 10 67.08 Quite High
Peritonitis 1 54.28 Quite High
Adhesions 1 44.72 Quite Low
Disease 5 18.80 Low Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, activation of Syk is involved in B-cell receptor signaling as well as Fc receptor-mediated antigen presentation.
Positive_regulation (activation) of Syk in B-cell
1) Confidence 0.20 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.42 Pain Relevance 0.14
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways.
Positive_regulation (role) of spleen tyrosine kinase in spleen
2) Confidence 0.04 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 18775507 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

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