INT154565

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
spleen 2
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 33 97.28 Very High Very High Very High
Inflammatory response 2 96.12 Very High Very High Very High
antagonist 1 84.72 Quite High
pregabalin 1 73.32 Quite High
agonist 1 72.72 Quite High
cytokine 3 57.08 Quite High
cINOD 1 46.88 Quite Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 97.28 Very High Very High Very High
Hypoxia 10 96.72 Very High Very High Very High
Hemangiosarcoma 139 94.76 High High
Cancer 85 84.08 Quite High
Metastasis 6 61.60 Quite High
Disease 12 34.76 Quite Low
Malignant Neoplastic Disease 25 5.00 Very Low Very Low Very Low
Hematoma 22 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Leukemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Signaling by each of these growth factors is partly dependent on activation of the phosphoinositide 3-kinase (PI3K) pathway, providing a possible connection between the processes of inflammation, hypoxia, and angiogenesis in the pathogenesis of hemangiosarcoma [22].
Regulation (dependent) of Positive_regulation (activation) of PI3K associated with inflammation, hypoxia and hemangiosarcoma
1) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2994824 Disease Relevance 1.25 Pain Relevance 0.26
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways.
Regulation (role) of Positive_regulation (activation) of phosphoinositide-3-kinase in spleen
2) Confidence 0.01 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 18775507 Disease Relevance 0.34 Pain Relevance 0.20

General Comments

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