INT154573

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LIPA) cell morphogenesis (LIPA) lipid metabolic process (LIPA)
lysosome (LIPA)
LIPA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 88.24 High High
Inflammation 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 12 99.52 Very High Very High Very High
Death 3 99.42 Very High Very High Very High
Wolman Disease 2 99.16 Very High Very High Very High
Apoptosis 7 88.56 High High
Abdominal Pain 2 88.24 High High
Atherosclerosis 17 64.08 Quite High
Rupture 3 43.12 Quite Low
Adhesions 1 36.64 Quite Low
Atherosclerotic Plaque 5 15.16 Low Low
Disease 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complete absence of lysosomal acid lipase activity results in Wolman disease and usually death in infancy, whereas partial deficiency of lysosomal acid lipase results in cholesteryl ester storage disease (CESD).
Spec (partial) Negative_regulation (deficiency) of lysosomal acid lipase associated with disorder of lipid metabolism, death and wolman disease
1) Confidence 0.52 Published 2008 Journal Clin. Chim. Acta Section Abstract Doc Link 18775687 Disease Relevance 0.73 Pain Relevance 0.09
Complete absence of lysosomal acid lipase activity results in Wolman disease and usually death in infancy, whereas partial deficiency of lysosomal acid lipase results in cholesteryl ester storage disease (CESD).
Negative_regulation (absence) of lysosomal acid lipase associated with disorder of lipid metabolism, death and wolman disease
2) Confidence 0.38 Published 2008 Journal Clin. Chim. Acta Section Abstract Doc Link 18775687 Disease Relevance 0.69 Pain Relevance 0.08
This drop in pH subsequently inactivates acid lipase and other hydrolases, leading to CE accumulation.
Negative_regulation (inactivates) of acid lipase
3) Confidence 0.01 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.24 Pain Relevance 0

General Comments

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