INT15458

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Context Info
Confidence 0.76
First Reported 1986
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 50
Total Number 52
Disease Relevance 22.67
Pain Relevance 23.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NPY) extracellular space (NPY) extracellular region (NPY)
cell (NPY)
Anatomy Link Frequency
plasma 5
CSF 3
tear 3
neurons 2
forearm 1
NPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 449 100.00 Very High Very High Very High
substance P 177 100.00 Very High Very High Very High
Enkephalin 90 100.00 Very High Very High Very High
Somatostatin 45 100.00 Very High Very High Very High
Cholecystokinin 32 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 99.90 Very High Very High Very High
orphanin 2 99.88 Very High Very High Very High
headache 52 99.60 Very High Very High Very High
Fibrositis 12 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lumbar Puncture Related Headaches 4 99.74 Very High Very High Very High
Infection 8 99.70 Very High Very High Very High
Headache 54 99.60 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 4 99.56 Very High Very High Very High
Sleep Disorders 22 99.44 Very High Very High Very High
Obesity 291 99.28 Very High Very High Very High
Cancer 24 99.24 Very High Very High Very High
Hypersensitivity 125 99.00 Very High Very High Very High
Arthritis 6 98.84 Very High Very High Very High
Conjunctiva Disease 30 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The semiquantitative mean densities (+/- SD) of periacinar NPY, VIP and GAL fibres expressed as a percentage of the total protein gene product (PGP) 9.5 immunoreactive fibres were 75.62 +/- 7.25%, 70.52 +/- 9.33% and 41.76 +/- 5.45%, respectively, whereas those of substance P (SP), calcitonin gene-related peptide (CGRP) and FMRF amide (FMRF) fibres were below 10%.
Gene_expression (expressed) of NPY associated with calcitonin gene-related peptide and substance p
1) Confidence 0.76 Published 1997 Journal Histochem. J. Section Abstract Doc Link 9279556 Disease Relevance 0 Pain Relevance 0.42
Gastric endocrine cells expressing 5-HT, glucagon, insulin, met-, leu-enkephalin, substance P, PYY, VIP, CCK, NPY, bombesin and motilin were unreactive for Trk-like proteins.
Gene_expression (expressing) of NPY in endocrine cells associated with enkephalin and substance p
2) Confidence 0.75 Published 1999 Journal Anat. Rec. Section Abstract Doc Link 10521780 Disease Relevance 0 Pain Relevance 0.32
First, Ptf1a appears to be a master regulator, as indicated by a requirement of Ptf1a for the expression of glycinergic marker GlyT2 and a set of peptides, including neuropeptide Y (NPY), nociceptin/orphanin FQ (N/OFQ), somatostatin (SOM), enkephalin (ENK), dynorphin (DYN) and galanin (GAL).
Gene_expression (expression) of NPY associated with dynorphin, orphanin, somatostatin, neuropeptide and enkephalin
3) Confidence 0.75 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.90
The presence of tyrosine hydroxylase, neuropeptide Y, vasoactive intestinal polypeptide, galanin, Met-enkephalin-Arg-Gly-Leu, substance P and calcitonin gene-related peptide was studied with immunohistochemistry in uterus-innervating neurones found in the inferior mesenteric ganglia after fluorescent tracer (Fast Blue) injection into different regions of the porcine uterus (uterine cervix, paracervical, middle and paraoviductal part of the uterine horn).
Gene_expression (presence) of neuropeptide Y in uterus associated with neuropeptide, enkephalin, calcitonin gene-related peptide and substance p
4) Confidence 0.75 Published 2003 Journal Anat Histol Embryol Section Abstract Doc Link 12823101 Disease Relevance 0.07 Pain Relevance 0.27
High levels of somatostatin, CCK octapeptide, neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) are found in cortical extracts.
Gene_expression (found) of neuropeptide Y associated with neuropeptide and somatostatin
5) Confidence 0.75 Published 1987 Journal Med. Biol. Section Abstract Doc Link 2821329 Disease Relevance 0.12 Pain Relevance 0.39
Both dentitions showed significant increases in CGRP, SP, VIP and NPY expression with caries progression.
Gene_expression (expression) of NPY in dentitions associated with substance p and calcitonin gene-related peptide
6) Confidence 0.68 Published 2002 Journal Arch. Oral Biol. Section Abstract Doc Link 12015218 Disease Relevance 0 Pain Relevance 0.80
NPY-IR was found to be evenly distributed throughout the amygdala.
Gene_expression (distributed) of NPY-IR in amygdala associated with amygdala
7) Confidence 0.67 Published 1986 Journal Acta Neuropathol. Section Abstract Doc Link 2948368 Disease Relevance 0.24 Pain Relevance 0.64
CGRP and NPY was found in higher concentrations in arthritic patients vs controls.
Gene_expression (found) of NPY associated with arthritis and calcitonin gene-related peptide
8) Confidence 0.66 Published 1991 Journal Scand. J. Rheumatol. Section Abstract Doc Link 1947895 Disease Relevance 0.61 Pain Relevance 0.92
CSF and plasma NPY-LI but not noradrenaline concentrations were higher in seropositive than in seronegative patients indicating that raised levels of NPY-LI did not result from a non-specific activation of the sympathetic nervous system.
Gene_expression (levels) of NPY in plasma associated with noradrenaline
9) Confidence 0.65 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.00 Pain Relevance 0.37
Significantly, peptide profiling provided novel insight into newly identified peptide products derived from proenkephalin, pro-NPY, proSAAS, CgA, CgB, and SCG2 prohormones.
Gene_expression (prohormones) of NPY
10) Confidence 0.65 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20704348 Disease Relevance 0.22 Pain Relevance 0.10
Galanin, neuropeptide Y, opioid peptides, growth hormone releasing hormone and desacetyl-MSH increase food intake whereas insulin, glucagon, cholecystokinin, anorectin, corticotropin releasing hormone, neurotensin, bombesin, enterostatin, cyclo-his-pro and thyrotropin-releasing hormone reduce food intake.
Gene_expression (reduce) of neuropeptide Y associated with neuropeptide, cholecystokinin and opioid
11) Confidence 0.65 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8489134 Disease Relevance 0 Pain Relevance 0.32
Galanin, neuropeptide Y, opioid peptides, growth-hormone-releasing hormone, and desacetyl-melanocyte stimulating hormone increase food intake whereas insulin, glucagon, cholecystokinin, anorectin, corticotropin-releasing hormone, neurotensin, bombesin, cyclo-his-pro, and thyrotropin-releasing hormone reduce food intake.
Gene_expression (reduce) of neuropeptide Y in melanocyte associated with neuropeptide, cholecystokinin and opioid
12) Confidence 0.65 Published 1992 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 1728838 Disease Relevance 0 Pain Relevance 0.32
In our study, no differences were found in SP, CGRP, NPY, and VIP tear levels of asymptomatic patients with allergic conjunctivitis and healthy non-allergic subjects.
Neg (no) Gene_expression (found) of NPY in tear associated with conjunctiva disease, hypersensitivity and substance p
13) Confidence 0.62 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.92 Pain Relevance 0.33
In our study, no differences were found in SP, CGRP, NPY, and VIP tear levels of asymptomatic patients with allergic conjunctivitis and healthy non-allergic subjects.
Gene_expression (levels) of NPY in tear associated with conjunctiva disease, hypersensitivity and substance p
14) Confidence 0.62 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.03 Pain Relevance 0.33
In conclusion, this study shows that NPY can be detected in microdialysis samples from human skeletal muscle and that addition of HSA to the perfusion medium increases the relative recovery in vitro.
Gene_expression (detected) of NPY in skeletal muscle
15) Confidence 0.60 Published 2004 Journal J. Neurosci. Methods Section Abstract Doc Link 14706716 Disease Relevance 0 Pain Relevance 0.06
NPY was detectable in 90% of the dialysates from the masseter and in 40% of the dialysates from the trapezius muscle.
Gene_expression (detectable) of NPY in muscle
16) Confidence 0.60 Published 2004 Journal J. Neurosci. Methods Section Abstract Doc Link 14706716 Disease Relevance 0 Pain Relevance 0.07
The primary aim of the present study was to compare plasma levels of SP, NPY and VIP in external jugular vein between patients with chronic tension-type headache and healthy controls.
Gene_expression (levels) of NPY in external jugular vein associated with headache and substance p
17) Confidence 0.59 Published 1999 Journal Pain Section Abstract Doc Link 10568863 Disease Relevance 0.42 Pain Relevance 0.78
Plasma levels of SP, NPY and VIP did not significantly differ between the peripheral and the cranial circulation neither in patients nor in controls (0.05).
Gene_expression (levels) of NPY in cranial associated with substance p
18) Confidence 0.59 Published 1999 Journal Pain Section Abstract Doc Link 10568863 Disease Relevance 0.71 Pain Relevance 1.20
In summary, the present study indicates that plasma levels of SP, NPY and VIP are normal in chronic tension-type headache patients and largely unrelated to headache state.
Gene_expression (levels) of NPY in plasma associated with headache and substance p
19) Confidence 0.59 Published 1999 Journal Pain Section Abstract Doc Link 10568863 Disease Relevance 0.79 Pain Relevance 1.09
NT2-N cells also expressed different neuropeptides, such as neuropeptide Y, oxytocin, vasopressin, calcitonin gene-related peptide, and Met- and Leu-enkephalin.
Gene_expression (expressed) of neuropeptide Y associated with neuropeptide, enkephalin and calcitonin gene-related peptide
20) Confidence 0.58 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10861514 Disease Relevance 0.23 Pain Relevance 0.56

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