INT154587

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna3)
Anatomy Link Frequency
DRG 1
Kcna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 8 98.84 Very High Very High Very High
Neuropathic pain 2 90.72 High High
Glutamate receptor 2 89.12 High High
Action potential 3 85.32 High High
tetrodotoxin 2 81.84 Quite High
Neuronal excitability 1 80.64 Quite High
potassium channel 2 79.00 Quite High
Painful diabetic neuropathy 2 75.00 Quite High
hyperexcitability 1 75.00 Quite High
GABAergic 2 69.40 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.84 Very High Very High Very High
Diabetes Mellitus 6 97.64 Very High Very High Very High
Neuropathic Pain 2 90.72 High High
Targeted Disruption 2 87.84 High High
Diabetic Neuropathy 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative RT-PCR analysis revealed that the mRNA levels of IA subunits, including Kv1.4, Kv3.4, Kv4.2, and Kv4.3, in the DRG were reduced approximately 50% in diabetic rats compared with those in control rats.
Transcription (levels) of Kv3 in DRG associated with dorsal root ganglion and diabetes mellitus
1) Confidence 0.38 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20557422 Disease Relevance 1.11 Pain Relevance 0.62
Chronic activity deprivation from 2 days in vitro (DIV) prevented the postnatal developmental increase of Kv3.2, but not Kv3.1b mRNA expression.
Transcription (expression) of Kv3
2) Confidence 0.32 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.09 Pain Relevance 0.24
Chronic activity deprivation from 2 days in vitro (DIV) prevented the postnatal developmental increase of Kv3.2, but not Kv3.1b mRNA expression.
Transcription (expression) of Kv3
3) Confidence 0.24 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

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