INT15459

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.89
Pain Relevance 8.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
plasma 1
spinal cord 1
follicle 1
thyroid 1
neurons 1
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 3 99.96 Very High Very High Very High
Neuropeptide 13 99.88 Very High Very High Very High
Enkephalin 4 99.62 Very High Very High Very High
narcan 9 99.60 Very High Very High Very High
Morphine 25 99.44 Very High Very High Very High
Pain 11 99.44 Very High Very High Very High
antagonist 25 99.42 Very High Very High Very High
withdrawal 14 99.08 Very High Very High Very High
opiate 19 99.02 Very High Very High Very High
Spinal cord 2 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 99.74 Very High Very High Very High
Cancer 17 99.60 Very High Very High Very High
Pain 8 99.44 Very High Very High Very High
Thyroid Hormone Resistance Syndrome 3 99.18 Very High Very High Very High
Eating Disorder 10 98.92 Very High Very High Very High
Reprotox - General 1 30 96.64 Very High Very High Very High
Hypoglycemia 3 96.48 Very High Very High Very High
Pituitary Cancer 17 96.12 Very High Very High Very High
Syndrome 7 95.36 Very High Very High Very High
Adenoma 16 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thyrotropin-releasing hormone, injected centrally at submicrogram doses, produced in nondependent, barbiturate-anesthetized animals, shaking behavior identical in its general features to that of morphine withdrawal.
Gene_expression (produced) of Thyrotropin-releasing hormone associated with withdrawal and morphine
1) Confidence 0.78 Published 1981 Journal Fed. Proc. Section Abstract Doc Link 6260535 Disease Relevance 0 Pain Relevance 0.52
Galanin, neuropeptide Y, opioid peptides, growth-hormone-releasing hormone, and desacetyl-melanocyte stimulating hormone increase food intake whereas insulin, glucagon, cholecystokinin, anorectin, corticotropin-releasing hormone, neurotensin, bombesin, cyclo-his-pro, and thyrotropin-releasing hormone reduce food intake.
Gene_expression (reduce) of thyrotropin-releasing hormone in melanocyte associated with neuropeptide, cholecystokinin and opioid
2) Confidence 0.65 Published 1992 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 1728838 Disease Relevance 0 Pain Relevance 0.31
In a second study indoprofen (400 mg, i.v., three times daily for 7 days) did not modify the PRL response to thyrotropin-releasing hormone nor serum GH levels.
Gene_expression (levels) of thyrotropin-releasing hormone
3) Confidence 0.65 Published 1983 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6354944 Disease Relevance 0.32 Pain Relevance 0.83
Pharmacological aspects of shaking behavior produced by TRH, AG-3-5, and morphine withdrawal.
Gene_expression (produced) of TRH associated with narcan, withdrawal and morphine
4) Confidence 0.65 Published 1981 Journal Fed. Proc. Section Title Doc Link 6260535 Disease Relevance 0 Pain Relevance 0.62
Role of spinal cord neuropeptides in pain sensitivity and analgesia: thyrotropin releasing hormone and vasopressin.
Gene_expression (hormone) of thyrotropin releasing hormone in spinal cord associated with pain, nociceptor, neuropeptide, analgesia and spinal cord
5) Confidence 0.65 Published 1986 Journal Brain Res. Section Title Doc Link 3080201 Disease Relevance 0.32 Pain Relevance 1.97
To investigate this hypothesis, we measured luteinizing hormone, follicle-stimulating hormone, and PRL levels in eumenorrheic and amenorrheic athletes during thyrotropin-releasing hormone and gonadotropin-releasing hormone tests at baseline, after naloxone infusions, after exercise to exhaustion, and after similar exercise during naloxone infusions.
Gene_expression (levels) of thyrotropin-releasing hormone in follicle associated with narcan
6) Confidence 0.65 Published 1991 Journal Fertil. Steril. Section Abstract Doc Link 1900478 Disease Relevance 0.17 Pain Relevance 0.37
Two to 6 months after successful tumor removal, serum PRL rose 2-fold (the usual criterion for a normal response) in 73% after TRH, in 100% after MCP, but in only 13% after CPZ and in only 14% on ITT.
Gene_expression (rose) of TRH associated with cancer
7) Confidence 0.65 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6775003 Disease Relevance 0.60 Pain Relevance 0.17
Levels of beta-endorphin, ACTH, FSH, LH, cortisol, prolactin and TRH were measured on the first and twentieth days after menses.
Gene_expression (Levels) of TRH
8) Confidence 0.58 Published 1990 Journal Int J Psychiatry Med Section Abstract Doc Link 2265889 Disease Relevance 0.10 Pain Relevance 0.29
A 34-year-old man with a GH-secreting pituitary macroadenoma and diabetes mellitus received an injection of 400 microg TRH, 100 microg GnRH, and 0.15 U/Kg regular insulin.
Gene_expression (injection) of TRH in pituitary associated with diabetes mellitus
9) Confidence 0.45 Published 2000 Journal Endocr. J. Section Abstract Doc Link 11036877 Disease Relevance 0.66 Pain Relevance 0.28
However, Schlienger et al showed that basal plasma levels of prolactin and delta prolactin response to TRH were increased in women on clomipramine but remained normal under maprotiline, in agreement with the different pharmacologic effect of these two classes of drugs, tricyclics mainly inhibiting serotonin, while tetracyclics rather norepinephrine recaptation (Schlienger et al 1980).
Gene_expression (response) of TRH in plasma associated with serotonin
10) Confidence 0.43 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.08 Pain Relevance 0.16
Other indirect methods to discriminate between thyroid hormone resistance and thyrotropinomas are the dissociated effects of TRH on TSH and ?
Gene_expression (effects) of TRH in thyroid associated with thyroid hormone resistance syndrome
11) Confidence 0.39 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.59 Pain Relevance 0.07
Anaesthesia blunted (P less than 0.01) the GH response to TRH in the immature cockerels, although the response was greater (P less than 0.05) than that in anesthetized adults.
Gene_expression (response) of TRH
12) Confidence 0.39 Published 1984 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 6439597 Disease Relevance 0 Pain Relevance 0
Neuropeptides like TRH, MIF, and cyclo (Leu-Gly) appear to produce similar results although their mechanism of action may be quite different.
Gene_expression (produce) of TRH associated with neuropeptide
13) Confidence 0.35 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742781 Disease Relevance 0.16 Pain Relevance 1.69
TRH expression was previously observed in the retinal amacrine cells of amphibians [47].
Gene_expression (expression) of TRH in amacrine cells
14) Confidence 0.28 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.50 Pain Relevance 0
The opiate receptor antagonist naloxone (5 mg/kg) was less effective than TRH in reversing the cardiovascular consequences of PAF administration.
Gene_expression (effective) of TRH associated with antagonist, narcan and opiate
15) Confidence 0.16 Published 1984 Journal Circ. Shock Section Abstract Doc Link 6432359 Disease Relevance 0.58 Pain Relevance 0.20
Methionine-enkephalin and thyroliberin (TRH) were present in a large number of neurons, while somatostatin, beta-melanotropin (MSH) and alpha-endorphin were occasionally seen in a few neurons.
Gene_expression (present) of TRH in neurons associated with somatostatin and enkephalin
16) Confidence 0.10 Published 1981 Journal C R Seances Acad Sci III Section Abstract Doc Link 6796212 Disease Relevance 0 Pain Relevance 0.39
The administration of TRH was unable to increase the circulating levels of GH in the normal controls, whereas it significantly increased GH concentrations in 5 of 7 bulimic women.
Gene_expression (administration) of TRH associated with eating disorder
17) Confidence 0.06 Published 1990 Journal Neuropsychobiology Section Abstract Doc Link 2126361 Disease Relevance 0.81 Pain Relevance 0.31

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