INT154603

Context Info Confidence 0.08 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 6.44 Pain Relevance 0.77

Hypism (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 8 98.92

Disease Link Frequency Relevance Heat Diabetes Mellitus 28 100.00 Pancreatic Cancer 24 100.00 Insulin Resistance 4 100.00 Hyperinsulinism 4 100.00 Pancreatitis 8 98.92 Disease 6 92.68 Malignant Neoplastic Disease 4 79.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Different clinical features of diabetes are associated with these two conditions: hyperinsulinemia and peripheral insulin resistance are the prevailing diabetic traits in pancreatic cancer, whereas reduced islet cell mass and impaired insulin secretion are typically observed in chronic pancreatitis.

Negative_regulation (reduced) of Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis

1) Confidence 0.08 Published 2008 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 18777459 Disease Relevance 1.55 Pain Relevance 0.19

Different clinical features of diabetes are associated with these two conditions: hyperinsulinemia and peripheral insulin resistance are the prevailing diabetic traits in pancreatic cancer, whereas reduced islet cell mass and impaired insulin secretion are typically observed in chronic pancreatitis.

Negative_regulation (impaired) of Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis

2) Confidence 0.08 Published 2008 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 18777459 Disease Relevance 1.55 Pain Relevance 0.19

Peripheral insulin resistance and hyperinsulinemia are the predominant diabetic traits in pancreatic cancer, while reduced islet cell mass and impaired insulin secretion are observed more often in chronic pancreatitis.

Negative_regulation (impaired) of Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis

3) Confidence 0.05 Published 2009 Journal Pancreatology Section Abstract Doc Link 19299909 Disease Relevance 1.67 Pain Relevance 0.19

Peripheral insulin resistance and hyperinsulinemia are the predominant diabetic traits in pancreatic cancer, while reduced islet cell mass and impaired insulin secretion are observed more often in chronic pancreatitis.

Negative_regulation (reduced) of Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis

4) Confidence 0.05 Published 2009 Journal Pancreatology Section Abstract Doc Link 19299909 Disease Relevance 1.67 Pain Relevance 0.19

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