INT15462

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 4.68
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
spinal nerve 1
macrophages 1
neuronal 1
Il1a (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 9 100.00 Very High Very High Very High
Eae 3 100.00 Very High Very High Very High
Sciatic nerve 3 100.00 Very High Very High Very High
allodynia 3 99.88 Very High Very High Very High
Inflammation 31 99.86 Very High Very High Very High
Morphine 7 99.50 Very High Very High Very High
Pain 18 99.42 Very High Very High Very High
dexamethasone 1 99.12 Very High Very High Very High
narcan 1 98.76 Very High Very High Very High
Spinal cord 2 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 15 100.00 Very High Very High Very High
Injury 3 100.00 Very High Very High Very High
INFLAMMATION 25 99.86 Very High Very High Very High
Pain 15 99.42 Very High Very High Very High
Depression 1 98.86 Very High Very High Very High
Nociception 9 95.76 Very High Very High Very High
Pressure And Volume Under Development 4 92.40 High High
Hyperalgesia 6 87.76 High High
Infection 1 84.08 Quite High
Death 1 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with naloxone and dexamethasone abolished morphine anti-inflammatory while decreasing IL-1 alpha serum levels, significantly.
Negative_regulation (decreasing) of IL-1 alpha associated with inflammation, narcan, dexamethasone and morphine
1) Confidence 0.59 Published 2002 Journal Cytokine Section Abstract Doc Link 12182845 Disease Relevance 0.52 Pain Relevance 0.67
A highly depressive effect on macrophage-mediated cytostatic activity and a decrease of IL-1 alpha and TNF levels were found in the supernatants of activated macrophages observed in morphine- and cocaine-treated mice.
Negative_regulation (decrease) of IL-1 alpha in macrophages associated with depression, cocaine and morphine
2) Confidence 0.53 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8407054 Disease Relevance 0.10 Pain Relevance 0.45
This neuronal loss was prevented by addition of interleukin-1 alpha, and to a lesser extent by interleukin-1 beta.
Negative_regulation (addition) of interleukin-1 alpha in neuronal
3) Confidence 0.39 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1729393 Disease Relevance 0.24 Pain Relevance 0.33
To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammatory, neuropathic, and post-operative pain models.
Negative_regulation (lacking) of IL-1alphabeta associated with pain, inflammation and neuropathic pain
4) Confidence 0.18 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.22 Pain Relevance 0.75
To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammatory, neuropathic, and post-operative pain models.
Negative_regulation (lacking) of IL-1alpha associated with pain, inflammation and neuropathic pain
5) Confidence 0.18 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.15 Pain Relevance 0.69
Finally, time to onset, duration, and magnitude of mechanical allodynia were reduced in two models of neuropathic pain, spinal nerve L5-L6 ligation and chronic constriction injury of the sciatic nerve, in IL-1alphabeta (-/-) mice versus controls.
Negative_regulation (reduced) of IL-1alphabeta in spinal nerve associated with allodynia, eae, injury, neuropathic pain and sciatic nerve
6) Confidence 0.17 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16256210 Disease Relevance 1.46 Pain Relevance 1.29

General Comments

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