INT154660

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.93
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 4
MMA 2
hmt1 (Zea mays)
Pain Term Frequency Confidence Heat
cINOD 1 99.98 Very High Very High Very High
peripheral neuropathy 13 99.20 Very High Very High Very High
IPN 7 98.84 Very High Very High Very High
iatrogenic 1 91.20 High High
Peripheral nervous system 1 85.92 High High
imagery 7 72.72 Quite High
Migraine 4 50.00 Quite Low
Angina 2 50.00 Quite Low
Glutamate 2 45.40 Quite Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
INFLAMMATION 1 99.86 Very High Very High Very High
Peripheral Neuropathy 13 99.20 Very High Very High Very High
Vascular Dementia 13 99.08 Very High Very High Very High
Disease 27 98.96 Very High Very High Very High
Stroke 122 93.04 High High
Cognitive Disorder 85 91.88 High High
Dementia 108 88.84 High High
Brain Hemorrhage 4 88.32 High High
Congenital Anomalies 5 85.88 High High
Cv General 3 Under Development 3 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patients with hyperhomocysteinaemia were treated with 5 mg of folic acid for 8 wk, and then rechecked the plasma levels of Hcy, folic acid and vitamin B(12) at the end of 4(th) and 8(th) wk.
Negative_regulation (rechecked) of Gene_expression (levels) of Hcy in plasma
1) Confidence 0.31 Published 2009 Journal Indian J. Med. Res. Section Body Doc Link 19491420 Disease Relevance 0.08 Pain Relevance 0
Nevertheless, genetic factors explained only a minor proportion of the variance for both Hcy plasma levels and for predicting MA phenotype.
Negative_regulation (predicting) of Gene_expression (levels) of Hcy in plasma
2) Confidence 0.11 Published 2010 Journal Headache Section Body Doc Link 19619240 Disease Relevance 0 Pain Relevance 0
Hcy levels and 6 polymorphisms corresponding to 6 folate-related genes, including the MTHFR C677T variant, were determined in all migraine participants and in a subset of 155 controls.
Spec (determined) Negative_regulation (determined) of Gene_expression (levels) of Hcy
3) Confidence 0.11 Published 2010 Journal Headache Section Body Doc Link 19619240 Disease Relevance 0 Pain Relevance 0
Schroecksnadel and colleagues84 documented that the use of antioxidant vitamins and anti-inflammatory drugs reduced the levels of Hcy and also the risk for vascular dementia.
Negative_regulation (reduced) of Gene_expression (levels) of Hcy associated with vascular dementia, inflammation and cinod
4) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695209 Disease Relevance 1.50 Pain Relevance 0.14
Cbl therapy led to improvements in Hcy and MMA levels in all groups, and PN in PD-IPN patients stabilized during therapy.
Negative_regulation (improvements) of Gene_expression (levels) of Hcy in MMA associated with ipn, peripheral neuropathy and disease
5) Confidence 0.03 Published 2008 Journal Mov. Disord. Section Abstract Doc Link 18785232 Disease Relevance 2.35 Pain Relevance 1.21

General Comments

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