INT15470

Context Info Confidence 0.48 First Reported 1987 Last Reported 2010 Negated 11 Speculated 3 Reported most in Abstract Documents 42 Total Number 45 Disease Relevance 26.10 Pain Relevance 18.25

Anatomy Link Frequency blood 2 spinal 1 nerve 1 nucleus 1 heart 1 CPP (Homo sapiens)

Pain Link Frequency Relevance Heat cva 973 100.00 anesthesia 59 100.00 Pain 45 100.00 isoflurane 30 100.00 pain pelvic 23 100.00 Morphine 19 100.00 Clonidine 5 100.00 tolerance 2 100.00 lidocaine 8 99.40 amygdala 5 99.36

Disease Link Frequency Relevance Heat Cv General 3 Under Development 924 100.00 Pain 36 100.00 Reprotox - General 3 24 100.00 Cerebral Aneurysm 8 99.96 Injury 106 99.84 Hypocapnia 5 99.82 Pressure And Volume Under Development 69 99.62 Syndrome 209 99.38 Nociception 3 98.90 Cv General 4 Under Development 79 98.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lesions of the mesolimbic dopamine system, the ventral pallidum, the lateral nucleus of the amygdala, or the caudate putamen had no effect on a morphine-induced CPP.

Neg (no) Regulation (effect) of CPP in nucleus associated with dopamine, amygdala and morphine

1) Confidence 0.48 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438800 Disease Relevance 0.23 Pain Relevance 0.77

Variation in StcO2 and BIS are associated with changes in ICP and CPP.

Regulation (changes) of CPP associated with cva

2) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.58

CONCLUSIONS: A guidelines text is presented including chapters on chronic prostate pain and bladder pain syndromes, urethral pain, scrotal pain, pelvic pain in gynaecologic practice, neurogenic dysfunctions, the role of the pelvic floor and pudendal nerve, psychological factors, general treatment of CPP, nerve blocks, and neuromodulation.

Regulation (chapters) of CPP in nerve

3) Confidence 0.33 Published 2010 Journal Eur. Urol. Section Body Doc Link 19733958 Disease Relevance 0 Pain Relevance 0

CONCLUSION: In the management of CPP, a non-surgical office-based therapy such as trigger point injections can be effective in selected patients.

Regulation (effective) of CPP

4) Confidence 0.33 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17195176 Disease Relevance 0 Pain Relevance 0

BURDEN OF SUFFERING: CPP is a common, debilitating condition affecting women.

Regulation (affecting) of CPP associated with pain pelvic

5) Confidence 0.29 Published 2005 Journal J Obstet Gynaecol Can Section Abstract Doc Link 19830953 Disease Relevance 0.46 Pain Relevance 0.46

The results confirm the critical influence of CPP and ti-pO2.

Regulation (influence) of CPP

6) Confidence 0.27 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9584925 Disease Relevance 0.47 Pain Relevance 0.09

Psychophysical testing consisted of determining CPP threshold, tolerance, intensity, unpleasantness and CPP threshold modulation by conditioning CPP.

Regulation (modulation) of CPP associated with pain and tolerance

7) Confidence 0.24 Published 2007 Journal Brain Res. Section Abstract Doc Link 17803974 Disease Relevance 1.06 Pain Relevance 1.19

Psychophysical testing consisted of determining CPP threshold, tolerance, intensity, unpleasantness and CPP threshold modulation by conditioning CPP.

Regulation (modulation) of CPP associated with pain and tolerance

8) Confidence 0.24 Published 2007 Journal Brain Res. Section Abstract Doc Link 17803974 Disease Relevance 1.07 Pain Relevance 1.20

Appropriate treatments were effective in restoring ti-pO2 with no change in CPP.

Neg (no) Regulation (change) of CPP

9) Confidence 0.24 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9584925 Disease Relevance 0.50 Pain Relevance 0.10

Chronic pelvic pain (CPP) is a disabling condition affecting 15 to 20% of U.S. women of reproductive age.

Regulation (affecting) of CPP associated with pain pelvic

10) Confidence 0.24 Published 2007 Journal Qual Health Res Section Abstract Doc Link 17478641 Disease Relevance 0.92 Pain Relevance 0.75

Sucrose solution given during place conditioning training had no effects on the expression, extinction, and reinstatement of CPP.

Neg (no) Regulation (effects) of CPP

11) Confidence 0.24 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18485463 Disease Relevance 0 Pain Relevance 0.78

We compared the effects of desflurane and isoflurane on cerebral perfusion pressure (CPP), lumbar cerebrospinal fluid pressure (LCSFP), and mean arterial blood pressure (MAP) in patients anesthetized with desflurane or isoflurane undergoing craniotomy for supratentorial mass lesions.

Regulation (effects) of CPP in blood associated with isoflurane

12) Confidence 0.24 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041612 Disease Relevance 0.07 Pain Relevance 0.42

Effect of diprivan on cerebral blood flow, intracranial (ICP) and cerebral perfused pressure (CPP) was studied in neurosurgical patients during induction narcosis.

Regulation (Effect) of CPP in blood associated with stupor

13) Confidence 0.23 Published 2001 Journal Anesteziol Reanimatol Section Abstract Doc Link 11494900 Disease Relevance 0.27 Pain Relevance 0.15

The changes in CPP paralleled MAP changes.

Regulation (changes) of CPP

14) Confidence 0.23 Published 1989 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815278 Disease Relevance 0.09 Pain Relevance 0.55

In conclusion, the thiopentone-isoflurane sequence and continuous propofol anesthesia provide similar hemodynamic conditions and responses to nociceptive stimuli; local lidocaine infiltration achieves better control of MAP, HR, CSFP, and CPP after HH application than the deepening of general anesthesia or intravenous fentanyl.

Regulation (control) of CPP associated with nociception, anesthesia, isoflurane and lidocaine

15) Confidence 0.23 Published 1989 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815278 Disease Relevance 0.10 Pain Relevance 0.48

The effect of clonidine on intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), heart rate (HR), and drug requirements was studied in 24 patients scheduled for elective cerebral tumor resection (ICP < or = 20 mm Hg).

Regulation (effect) of CPP in heart associated with cva, brain tumor and clonidine

16) Confidence 0.23 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7549366 Disease Relevance 0.60 Pain Relevance 0.68

While grandmultiparity had a significant effect on CPP (p < 0.0001), it did not have a significant effect on other pain types in a MANOVA model.

Regulation (effect) of CPP associated with pain and pain pelvic

17) Confidence 0.23 Published 1999 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 10461003 Disease Relevance 2.29 Pain Relevance 2.63

CAP Index has an additional association with survival, good neurological outcome, and lack of need for interventions to lower ICP, independent of ICP and CPP.

Neg (independent) Regulation (independent) of CPP associated with cva

18) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.55

There are 1,883 concurrent, hourly observations of ICP, CPP, BIS and StcO2 values.

Regulation (values) of CPP associated with cva

19) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.77 Pain Relevance 0.31

The aim of the current study was to examine the effects of 10 degrees reverse Trendelenburg position (rTp) on subdural intracranial pressure (ICP), cerebral perfusion pressure (CPP), and dural tension.

Spec (examine) Regulation (effects) of CPP associated with cva

20) Confidence 0.20 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16369135 Disease Relevance 0.74 Pain Relevance 0.40

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