INT154706

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.95
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tg) extracellular region (Tg) Golgi apparatus (Tg)
endoplasmic reticulum (Tg)
Anatomy Link Frequency
vesicles 2
plasma 1
epithelial cells 1
spleen 1
brainstem 1
Tg (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 87 99.98 Very High Very High Very High
medulla 16 98.50 Very High Very High Very High
Pain 6 96.24 Very High Very High Very High
Spinal cord 70 84.04 Quite High
Inflammation 50 64.16 Quite High
tolerance 9 62.20 Quite High
fibrosis 2 10.08 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 99.00 Very High Very High Very High
Skin Cancer 22 97.28 Very High Very High Very High
Pain 5 96.24 Very High Very High Very High
Sprains And Strains 7 94.32 High High
Metastasis 11 94.08 High High
Ocular Toxicity (including Many Sub-types) 1 92.72 High High
Thyroid Neoplasm 5 91.88 High High
Lymphocytic Choriomeningitis 2 91.80 High High
Carcinoma 6 90.96 High High
Adenoma 1 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subsequent whole body scan and serum thyroglobulin determination were negative.
Neg (negative) Gene_expression (negative) of thyroglobulin in body
1) Confidence 0.38 Published 2008 Journal Am. J. Med. Sci. Section Abstract Doc Link 18794628 Disease Relevance 0.43 Pain Relevance 0.10
Immunohistochemistry showed pancytokeratin positivity while thyroglobulin and calcitonin were negative.
Neg (negative) Gene_expression (negative) of thyroglobulin
2) Confidence 0.15 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1847680 Disease Relevance 1.41 Pain Relevance 0
This PS1-PLD1 interaction recruits PLD1 to the Golgi/TGN and thus potentially alters APP trafficking as PLD1 overexpression promotes budding of vesicles from the TGN containing APP and increases cell surface levels of APP [176,177].
Gene_expression (containing) of TGN in vesicles
3) Confidence 0.13 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.20 Pain Relevance 0
The cleavage of various substrates appears to be dependent on the subcellular compartment; APP is mainly cleaved in the TGN and early endosomal domains whereas Notch is primarily cleaved at the plasma membrane [34,36,123].
Gene_expression (cleaved) of TGN in plasma
4) Confidence 0.13 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.08 Pain Relevance 0
The ANOVA comparing COG distances A versus B were not significant between hemispheres or sessions (Table 3).
Gene_expression (distances) of COG
5) Confidence 0.12 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0.11 Pain Relevance 0
Furthermore, the virus that was shown to persist mainly in the thyroid epithelial cells in which thyroglobulin is synthesized induced a reduction in the level of thyroglobulin messenger RNA and circulating thyroid hormones, but there was no thyroid cell destruction.
Gene_expression (synthesized) of thyroglobulin in epithelial cells
6) Confidence 0.08 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.83 Pain Relevance 0.06
-secretase complex were found to co-reside in lipid raft microdomains with VAMP-4 (TGN), syntaxin 6 (TGN vesicles) and syntaxin 13 (late endosomes).
Gene_expression (vesicles) of TGN in vesicles
7) Confidence 0.08 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.14 Pain Relevance 0
Examples of tissue specific patterns are those of MUC1, CEA, PSA, thyroglobulin, and calcitonin whereas tumour selective patterns include HER2 FGFR4 and VEGF [97].
Gene_expression (those) of thyroglobulin associated with cancer
8) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.74 Pain Relevance 0.03
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Gene_expression (expressions) of hTgn in spleen
9) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.17
mRNA expression in the brainstem between cell-treated and non-treated G93A mice; all showing high cytokine expression vs. control hTgn or C57BL/6 mice: Media (p<0.01), CsA (p<0.001), MNC hUCB 10×106 (p<0.05), MNC hUCB 25×106 (p<0.05), and MNC hUCB 50×106 (p<0.01).
Gene_expression (expression) of hTgn in brainstem associated with medulla and cytokine
10) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.29

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