INT154706

Context Info Confidence 0.38 First Reported 2003 Last Reported 2011 Negated 2 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 4.95 Pain Relevance 0.64

extracellular space (Tg) extracellular region (Tg) Golgi apparatus (Tg) endoplasmic reticulum (Tg)

Anatomy Link Frequency vesicles 2 plasma 1 epithelial cells 1 spleen 1 brainstem 1 Tg (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 87 99.98 medulla 16 98.50 Pain 6 96.24 Spinal cord 70 84.04 Inflammation 50 64.16 tolerance 9 62.20 fibrosis 2 10.08 Kinase C 12 5.00 anesthesia 6 5.00 cINOD 5 5.00

Disease Link Frequency Relevance Heat Cancer 150 99.00 Skin Cancer 22 97.28 Pain 5 96.24 Sprains And Strains 7 94.32 Metastasis 11 94.08 Ocular Toxicity (including Many Sub-types) 1 92.72 Thyroid Neoplasm 5 91.88 Lymphocytic Choriomeningitis 2 91.80 Carcinoma 6 90.96 Adenoma 1 90.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A subsequent whole body scan and serum thyroglobulin determination were negative.

Neg (negative) Gene_expression (negative) of thyroglobulin in body

1) Confidence 0.38 Published 2008 Journal Am. J. Med. Sci. Section Abstract Doc Link 18794628 Disease Relevance 0.43 Pain Relevance 0.10

Immunohistochemistry showed pancytokeratin positivity while thyroglobulin and calcitonin were negative.

Neg (negative) Gene_expression (negative) of thyroglobulin

2) Confidence 0.15 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1847680 Disease Relevance 1.41 Pain Relevance 0

This PS1-PLD1 interaction recruits PLD1 to the Golgi/TGN and thus potentially alters APP trafficking as PLD1 overexpression promotes budding of vesicles from the TGN containing APP and increases cell surface levels of APP [176,177].

Gene_expression (containing) of TGN in vesicles

3) Confidence 0.13 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.20 Pain Relevance 0

The cleavage of various substrates appears to be dependent on the subcellular compartment; APP is mainly cleaved in the TGN and early endosomal domains whereas Notch is primarily cleaved at the plasma membrane [34,36,123].

Gene_expression (cleaved) of TGN in plasma

4) Confidence 0.13 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.08 Pain Relevance 0

The ANOVA comparing COG distances A versus B were not significant between hemispheres or sessions (Table 3).

Gene_expression (distances) of COG

5) Confidence 0.12 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0.11 Pain Relevance 0

Furthermore, the virus that was shown to persist mainly in the thyroid epithelial cells in which thyroglobulin is synthesized induced a reduction in the level of thyroglobulin messenger RNA and circulating thyroid hormones, but there was no thyroid cell destruction.

Gene_expression (synthesized) of thyroglobulin in epithelial cells

6) Confidence 0.08 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.83 Pain Relevance 0.06

-secretase complex were found to co-reside in lipid raft microdomains with VAMP-4 (TGN), syntaxin 6 (TGN vesicles) and syntaxin 13 (late endosomes).

Gene_expression (vesicles) of TGN in vesicles

7) Confidence 0.08 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.14 Pain Relevance 0

Examples of tissue specific patterns are those of MUC1, CEA, PSA, thyroglobulin, and calcitonin whereas tumour selective patterns include HER2 FGFR4 and VEGF [97].

Gene_expression (those) of thyroglobulin associated with cancer

8) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.74 Pain Relevance 0.03

Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.

Gene_expression (expressions) of hTgn in spleen

9) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.17

mRNA expression in the brainstem between cell-treated and non-treated G93A mice; all showing high cytokine expression vs. control hTgn or C57BL/6 mice: Media (p<0.01), CsA (p<0.001), MNC hUCB 10×106 (p<0.05), MNC hUCB 25×106 (p<0.05), and MNC hUCB 50×106 (p<0.01).

Gene_expression (expression) of hTgn in brainstem associated with medulla and cytokine

10) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.29

General Comments

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