INT154709

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rnf13) Golgi apparatus (Rnf13) endoplasmic reticulum (Rnf13)
nucleus (Rnf13) ligase activity (Rnf13)
Rnf13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 95.84 Very High Very High Very High
Chronic pancreatitis 2 89.12 High High
Disease Link Frequency Relevance Heat
Cancer 10 99.72 Very High Very High Very High
Adenocarcinoma 6 98.74 Very High Very High Very High
Pancreatitis 2 89.12 High High
Pancreatic Cancer 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over-expression of wild type but not RING domain-mutant RNF13 in pancreatic MiaPaca-2 cancer cells increased invasive potential and gelatinolytic activity by matrix metalloproteinase-9.
Neg (not) Positive_regulation (Over-expression) of Gene_expression (Over-expression) of RNF13 associated with cancer and metalloproteinase
1) Confidence 0.35 Published 2009 Journal Cell Res. Section Abstract Doc Link 18794910 Disease Relevance 0.85 Pain Relevance 0.14
Immunohistochemical analysis of pancreatic ductal adenocarcinoma (PDAC) and paracancerous normal tissues from 72 patients documented RNF13 over-expression in 30 tumor samples (41.7%, 30/72), and its expression was significantly associated with histological grading (P = 0.024).
Positive_regulation (over-expression) of Gene_expression (over-expression) of RNF13 associated with adenocarcinoma and cancer
2) Confidence 0.35 Published 2009 Journal Cell Res. Section Abstract Doc Link 18794910 Disease Relevance 0.80 Pain Relevance 0.08

General Comments

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