INT154710

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UBR1) ligase activity (UBR1) cytoplasm (UBR1)
Anatomy Link Frequency
colon 1
UBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
Chronic pancreatitis 1 72.24 Quite High
metalloproteinase 2 53.96 Quite High
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2 99.84 Very High Very High Very High
Colon Cancer 40 99.48 Very High Very High Very High
Cancer 21 96.12 Very High Very High Very High
Stomach Cancer 2 93.40 High High
Apoptosis 41 93.08 High High
Shock 1 88.16 High High
Stress 31 85.68 High High
Adenocarcinoma 7 84.48 Quite High
Pancreatitis 1 72.24 Quite High
Starvation 2 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of various ubiquitin cycle-related genes (FBOX5, FBOX11, MAP1LC3B, SENP6, TBL1X, UBE2C, UBR1, Ufm1, USP3) were influenced by black cohosh.
Gene_expression (expression) of UBR1
1) Confidence 0.47 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.68 Pain Relevance 0
RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer.
Gene_expression (expressed) of ligase associated with pancreatic cancer
2) Confidence 0.01 Published 2009 Journal Cell Res. Section Title Doc Link 18794910 Disease Relevance 0.77 Pain Relevance 0.10
Isothiocyanates induced protein expression of AKR1C1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and heavy subunit of glutamate-cysteine ligase (GCLC) in a colon cancer cell line [43].
Gene_expression (expression) of ligase in colon associated with glutamate and colon cancer
3) Confidence 0.01 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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