INT154727

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2b2) aging (Cyp2b2) endoplasmic reticulum (Cyp2b2)
Anatomy Link Frequency
liver 1
Cyp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 14 100.00 Very High Very High Very High
sSRI 12 100.00 Very High Very High Very High
tricyclic antidepressant 2 100.00 Very High Very High Very High
Paracetamol 8 90.88 High High
Endep 2 75.12 Quite High
Desipramine 8 71.60 Quite High
fluoxetine 6 70.56 Quite High
noradrenaline 2 25.00 Low Low
Serotonin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver.
Regulation (Effect) of CYP2B in liver associated with antidepressant
1) Confidence 0.25 Published 2008 Journal Pharmacol Rep Section Title Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.57
The aim of the present study was to investigate the influence of antidepressants with different chemical structures and mechanisms of action affecting serotonergic and/or noradrenergic systems - tricyclic antidepressant drugs (TAD), selective serotonin reuptake inhibitors (SSRIs) and novel antidepressants (mirtazapine, nefazodone) - on the activity of rat CYP2B measured as the rate of 16beta-hydroxylation of testosterone.
Regulation (affecting) of CYP2B associated with antidepressant, ssri and tricyclic antidepressant
2) Confidence 0.22 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.57
The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.
Regulation (regulation) of CYP2B
3) Confidence 0.05 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.62

General Comments

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