INT154727

Context Info Confidence 0.25 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0 Pain Relevance 1.76

oxidoreductase activity (Cyp2b2) aging (Cyp2b2) endoplasmic reticulum (Cyp2b2)

Anatomy Link Frequency liver 1 Cyp2b2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antidepressant 14 100.00 sSRI 12 100.00 tricyclic antidepressant 2 100.00 Paracetamol 8 90.88 Endep 2 75.12 Desipramine 8 71.60 fluoxetine 6 70.56 noradrenaline 2 25.00 Serotonin 2 25.00

Disease Link Frequency Relevance Heat Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver.

Regulation (Effect) of CYP2B in liver associated with antidepressant

1) Confidence 0.25 Published 2008 Journal Pharmacol Rep Section Title Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.57

The aim of the present study was to investigate the influence of antidepressants with different chemical structures and mechanisms of action affecting serotonergic and/or noradrenergic systems - tricyclic antidepressant drugs (TAD), selective serotonin reuptake inhibitors (SSRIs) and novel antidepressants (mirtazapine, nefazodone) - on the activity of rat CYP2B measured as the rate of 16beta-hydroxylation of testosterone.

Regulation (affecting) of CYP2B associated with antidepressant, ssri and tricyclic antidepressant

2) Confidence 0.22 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.57

The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.

Regulation (regulation) of CYP2B

3) Confidence 0.05 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.62

General Comments

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