INT15474

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 22.32
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
fibroblasts 3
ZR-75-1 2
PGE2 2
osteoblasts 2
plasma 1
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 121 99.84 Very High Very High Very High
metalloproteinase 198 99.76 Very High Very High Very High
Inflammatory mediators 2 99.76 Very High Very High Very High
Inflammation 85 99.42 Very High Very High Very High
Angina 11 99.08 Very High Very High Very High
COX2 4 98.32 Very High Very High Very High
cytokine 49 98.20 Very High Very High Very High
cINOD 21 96.88 Very High Very High Very High
Osteoarthritis 78 96.72 Very High Very High Very High
headache 5 89.72 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 46 99.96 Very High Very High Very High
Rheumatoid Arthritis 121 99.84 Very High Very High Very High
Glioma 26 99.84 Very High Very High Very High
Breast Cancer 188 99.76 Very High Very High Very High
Adhesions 208 99.60 Very High Very High Very High
Cv Unclassified Under Development 2 99.54 Very High Very High Very High
Necrosis 10 99.46 Very High Very High Very High
INFLAMMATION 95 99.42 Very High Very High Very High
Cancer 482 99.28 Very High Very High Very High
Cv General 3 Under Development 11 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated.
Gene_expression (expression) of uPAR in fibroblasts associated with necrosis, inflammation, cancer and peptic ulcer
1) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.56 Pain Relevance 0.09
Furthermore, we investigated the role of prostaglandin E2 (PGE2), which is suggested to play major roles in acute inflammation of the stomatch, on uPA and uPAR expression in gastric fibroblasts.
Gene_expression (expression) of uPAR in fibroblasts associated with inflammation
2) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.28 Pain Relevance 0.12
The expression level of uPAR mRNA and the amount of uPA antigen on cell surfaces increased in a dose-dependent manner on treatment with PGE2 (10 and 50 ng/ml).
Gene_expression (expression) of uPAR mRNA in PGE2
3) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.22 Pain Relevance 0.13
The expression level of uPAR mRNA increased in a dose-dependent manner on IL-1beta stimulation.
Gene_expression (expression) of uPAR mRNA
4) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.46 Pain Relevance 0.07
The increased uPAR mRNA expression caused by IL-1beta was reduced to the basal level by treatment with 50 microM indomethacin.
Gene_expression (expression) of uPAR mRNA
5) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.45 Pain Relevance 0.15
These results suggest that uPA and uPAR expression in gastric fibroblasts is involved in the regulating system of PGE2 and that NSAIDs may delay healing of gastric mucosal injury in part through suppressing uPA production via inhibition of endogenous PG production.
Gene_expression (expression) of uPAR in PGE2 associated with injury and cinod
6) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.26 Pain Relevance 0.14
The effect of indomethacin on uPA and uPAR expression in these cells was also examined.
Gene_expression (expression) of uPAR
7) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.49 Pain Relevance 0.10
In acute inflammatory condition, little is known about the expression of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in the gastric fibroblasts.
Gene_expression (expression) of uPAR in fibroblasts associated with inflammation
8) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.53 Pain Relevance 0.10
Mouse pre-B lymphocytes (BAF3 cells) transfected with various amounts of uPAR complementary DNA showed a strong correlation of uPAR expression with beta(2)-integrin-dependent adhesion to intercellular adhesion molecule 1, thus providing evidence for the functional relevance of uPAR up-regulation in an isolated in vitro system.
Gene_expression (expression) of uPAR in pre-B lymphocytes associated with adhesions
9) Confidence 0.69 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.31 Pain Relevance 0.09
In conclusion, we found that uPAR expression is elevated on monocytes in AMI and contributes to enhanced cell adhesion.
Gene_expression (expression) of uPAR in monocytes associated with adhesions and myocardial infarction
10) Confidence 0.69 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.21 Pain Relevance 0.04
Expression of uPAR correlated with activation of beta(2)-integrins lymphocyte function-associated antigen 1 (LFA-1) and macrophage antigen 1 (Mac-1), measured by using monoclonal antibodies (mAbs) 24 and CBRM1/5.
Gene_expression (Expression) of uPAR in lymphocyte
11) Confidence 0.69 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 0.90 Pain Relevance 0.10
Incubation of monocytic MonoMac6 cells with plasma from patients with AMI enhanced uPAR messenger RNA expression and cell adhesion to HUVECs.
Gene_expression (expression) of uPAR in plasma associated with adhesions and myocardial infarction
12) Confidence 0.69 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.58 Pain Relevance 0.06
In 20 patients with AMI, uPAR surface expression (measured by flow cytometry) was increased compared with that in patients with chronic stable angina (mean +/- SD fluorescence, 179 +/- 96 vs 80 +/- 53; P =.002).
Gene_expression (expression) of uPAR associated with angina and myocardial infarction
13) Confidence 0.60 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 0.85 Pain Relevance 0.10
Similar differences, although less pronounced, were observed for cyclooxygenase 2 (COX-2; also known as PTGS2; p < 0.001), urokinase plasminogen activator receptor (uPAR; also known as PLAUR; p = 0.003) and matrix metalloproteinase 1 (MMP1; p = 0.03).
Gene_expression (0.003) of uPAR associated with metalloproteinase and cox2
14) Confidence 0.52 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.12 Pain Relevance 0.13
Analysis on a gene-by-gene basis demonstrated higher expression levels of PAI-1, COX-2, uPAR and MMP1 in STs compared to their paired CBs, whereas no changes were observed for all other genes.
Gene_expression (levels) of uPAR
15) Confidence 0.47 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.74 Pain Relevance 0.12
Analysis on a gene-by-gene basis demonstrated higher expression levels of PAI-1, COX-2, uPAR and MMP1 in STs compared to their paired CBs, whereas no changes were observed for all other genes.
Gene_expression (expression) of uPAR
16) Confidence 0.47 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.75 Pain Relevance 0.12
In addition, expression of urokinase-type plasminogen activator receptor (PLAUR) was upregulated by curcumin (Figure 3).
Gene_expression (expression) of PLAUR
17) Confidence 0.45 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.46 Pain Relevance 0
there was increased expression of both u-PA and u-PAR by the breast cancer cells (Fig. 4B; ZR-75-1 cells shown, results similar with all 3 breast cancer cell lines.).
Gene_expression (expression) of u-PAR in ZR-75-1 associated with breast cancer
18) Confidence 0.42 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 1.08 Pain Relevance 0.14
All 3 breast cancer cell lines expressed u-PA and u-PAR (Fig. 4A; ZR-75-1 cells shown, results similar with all 3 breast cancer cell lines) and upon stimulation with TGF?
Gene_expression (expressed) of u-PAR in ZR-75-1 associated with breast cancer
19) Confidence 0.42 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 1.11 Pain Relevance 0.14
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Gene_expression (expression) of PLAUR
20) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.70 Pain Relevance 0

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