INT154746

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
podocytes 2
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 93.72 High High
aspirin 1 53.52 Quite High
cINOD 1 52.80 Quite High
Inflammation 1 36.32 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 1 64.96 Quite High
Cancer 1 64.60 Quite High
INFLAMMATION 2 52.56 Quite High
Stress 1 47.88 Quite Low
Repression 1 46.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggested that indomethacin suppressed the response of podocytes to TNF-alpha via UPR and that UPR-triggered induction of GRP78 and degradation of TRAF2 may be responsible, at least in part, for the suppressive effect of indomethacin.
Regulation (responsible) of Positive_regulation (induction) of GRP78 in podocytes
1) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.18 Pain Relevance 0.16

General Comments

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