INT154750

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Traf2) signal transduction (Traf2) enzyme binding (Traf2)
protein complex assembly (Traf2) protein complex (Traf2) ligase activity (Traf2)
Anatomy Link Frequency
podocytes 2
Traf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 93.72 High High
aspirin 3 73.76 Quite High
cINOD 3 73.04 Quite High
Inflammation 3 56.56 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 85.20 High High
Cancer 3 84.84 Quite High
INFLAMMATION 6 72.80 Quite High
Stress 3 68.12 Quite High
Repression 3 66.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reporter assays showed that indomethacin as well as thapsigargin attenuated activation of NF-kappaB by TNF-alpha, and it was associated with enhanced degradation of TNF receptor-associated factor 2 (TRAF2) and blunted degradation of IkappaBbeta.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of TNF receptor-associated factor 2
1) Confidence 0.60 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.43 Pain Relevance 0.21
These results suggested that indomethacin suppressed the response of podocytes to TNF-alpha via UPR and that UPR-triggered induction of GRP78 and degradation of TRAF2 may be responsible, at least in part, for the suppressive effect of indomethacin.
Positive_regulation (induction) of Protein_catabolism (degradation) of TRAF2 in podocytes
2) Confidence 0.44 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.18 Pain Relevance 0.16
Reporter assays showed that indomethacin as well as thapsigargin attenuated activation of NF-kappaB by TNF-alpha, and it was associated with enhanced degradation of TNF receptor-associated factor 2 (TRAF2) and blunted degradation of IkappaBbeta.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of TRAF2
3) Confidence 0.44 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.43 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox