INT154755

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.70
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Ccl2) extracellular region (Tnf, Ccl2) intracellular (Tnf)
extracellular matrix organization (Tnf) cytoplasm (Ccl2) cell proliferation (Tnf)
Anatomy Link Frequency
monocyte 2
Tnf (Mus musculus)
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 94.88 High High
chemokine 3 92.04 High High
cytokine 19 75.00 Quite High
cINOD 3 63.84 Quite High
aspirin 1 60.08 Quite High
Inflammatory stimuli 1 40.96 Quite Low
Inflammatory marker 5 40.24 Quite Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 50 94.88 High High
Diabetes Mellitus 5 88.52 High High
Hyperlipidemia 1 86.88 High High
Atherosclerosis 46 86.52 High High
Myocardial Infarction 5 83.12 Quite High
Disorder Of Lipid Metabolism 3 81.92 Quite High
Targeted Disruption 2 80.56 Quite High
Repression 1 74.16 Quite High
Cardiovascular Disease 6 72.48 Quite High
Stress 2 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen.
TNF-alpha Positive_regulation (response) of Gene_expression (expression) of monocyte chemoattractant protein 1 in monocyte
1) Confidence 0.23 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.30 Pain Relevance 0.18
MCP-1 expression can be induced by IL-1b and TNF-alpha through the activation of nuclear factor-kB [70, 71].
TNF-alpha Positive_regulation (induced) of Gene_expression (expression) of MCP-1
2) Confidence 0.06 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.40 Pain Relevance 0.09

General Comments

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