INT154756

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf, Nfkb1) mitochondrion (Nfkb1) intracellular (Tnf)
DNA binding (Nfkb1) extracellular matrix organization (Tnf) protein complex (Nfkb1)
Tnf (Mus musculus)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 97.48 Very High Very High Very High
aspirin 2 76.36 Quite High
cINOD 2 75.64 Quite High
Inflammation 2 59.16 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 87.80 High High
Cancer 2 87.44 High High
INFLAMMATION 4 75.40 Quite High
Stress 2 70.72 Quite High
Repression 2 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reporter assays showed that indomethacin as well as thapsigargin attenuated activation of NF-kappaB by TNF-alpha, and it was associated with enhanced degradation of TNF receptor-associated factor 2 (TRAF2) and blunted degradation of IkappaBbeta.
TNF-alpha Positive_regulation (activation) of NF-kappaB
1) Confidence 0.31 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.45 Pain Relevance 0.22
Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB.
TNF-alpha Positive_regulation (activation) of NF-kappaB associated with cytokine
2) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.33 Pain Relevance 0.18

General Comments

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