INT154757

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0.22

signal transduction (Tnf, Nfkb1) mitochondrion (Nfkb1) intracellular (Tnf) DNA binding (Nfkb1) extracellular matrix organization (Tnf) protein complex (Nfkb1)

Tnf (Mus musculus) Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat aspirin 1 76.80 cINOD 1 76.08 cytokine 2 75.00 Inflammation 1 59.60

Disease Link Frequency Relevance Heat Necrosis 1 88.24 Cancer 1 87.88 INFLAMMATION 2 75.84 Stress 1 71.16 Repression 1 69.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reporter assays showed that indomethacin as well as thapsigargin attenuated activation of NF-kappaB by TNF-alpha, and it was associated with enhanced degradation of TNF receptor-associated factor 2 (TRAF2) and blunted degradation of IkappaBbeta.

Negative_regulation (attenuated) of TNF-alpha Positive_regulation (activation) of NF-kappaB

1) Confidence 0.19 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.45 Pain Relevance 0.22

General Comments

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