INT154768

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 7.05
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATM) signal transduction (ATM) cell death (ATM)
cytoplasmic membrane-bounded vesicle (ATM) nucleus (ATM) DNA binding (ATM)
Anatomy Link Frequency
blood 1
lung 1
T cells 1
ATM (Homo sapiens)
ATM - C103T (1)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Crohn's disease 21 88.20 High High
depression 2 87.20 High High
imagery 4 76.52 Quite High
cytokine 5 49.28 Quite Low
Inflammation 8 48.88 Quite Low
headache 5 25.00 Low Low
midbrain 1 8.36 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Telangiectasia 8 100.00 Very High Very High Very High
Sprains And Strains 492 99.54 Very High Very High Very High
Leukemia 10 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 98.80 Very High Very High Very High
Adenocarcinoma 3 98.60 Very High Very High Very High
Death 4 97.04 Very High Very High Very High
Stress 13 94.28 High High
Ataxia 19 93.52 High High
Cough 1 93.20 High High
Pressure And Volume Under Development 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lastly, genetic testing of our patient showed a deletion of p53 and ATM genes and the presence of the rearrangement of BCL6 gene.
Negative_regulation (deletion) of ATM
1) Confidence 0.57 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2277428 Disease Relevance 1.31 Pain Relevance 0.22
INTRODUCTION: Losartan potassium, an orally active, highly selective AT1 angiotensin II receptor inhibitor, effectively reduces blood pressure by direct receptor blockade, thereby lessening the likelihood of angiotensin converting enzyme (ACE) inhibitor-associated side effects such as dry cough or possibly angioedema.
Negative_regulation (inhibitor) of AT1 in blood associated with pressure and volume under development and cough
2) Confidence 0.42 Published 1995 Journal J Hypertens Suppl Section Abstract Doc Link 18800454 Disease Relevance 0.26 Pain Relevance 0
AIM: To examine the safety profile and tolerability of losartan potassium (losartan), a selective antagonist of the angiotensin II type 1 (AT1) receptor.
Negative_regulation (antagonist) of AT1 associated with antagonist
3) Confidence 0.42 Published 1995 Journal J Hypertens Suppl Section Abstract Doc Link 18800461 Disease Relevance 0 Pain Relevance 0.05
Detection of the ATM C103T mutation [17] and genotyping of 24 SNPs including the rs7294 (VKORC1 9041G/A) [18] were carried out using the SEQUENOM MassArray MALDI-TOF mass spectrometer.
Negative_regulation (Detection) of ATM (C103T)
4) Confidence 0.39 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2642879 Disease Relevance 0.23 Pain Relevance 0.04
Experiments in A 549 lung adenocarcinoma and in K562 erythroblastoid leukaemia cells have shown that caffeine inhibits ATM and ATR kinases which control checkpoints via phosphorylation of p53 thereby maintaining the G2 block and controlling HR repair [21,24,32,48,51].
Negative_regulation (inhibits) of ATM in lung associated with adenocarcinoma and leukemia
5) Confidence 0.18 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.29 Pain Relevance 0.04
Inhibiting ATM kinase activity efficiently blocked HIV replication in T cells by inducing cell death in the infected cells, most probably as a result of an impaired ability to repair DNA double-stranded breaks arising from retroviral genome integration.
Negative_regulation (Inhibiting) of ATM kinase in T cells associated with telangiectasia, acquired immune deficiency syndrome or hiv infection and death
6) Confidence 0.14 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 1.43 Pain Relevance 0
The close structural and functional relationship between Caffeine and Pentoxifylline strongly suggests that ATM inhibition also applies to Pentoxifylline.
Negative_regulation (inhibition) of ATM
7) Confidence 0.13 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.31 Pain Relevance 0.04
A clue to the molecular factors involved came from a recent report showing that activation or inhibition of the DNA damage sensor ATM is of importance [58].
Negative_regulation (inhibition) of ATM
8) Confidence 0.12 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998878 Disease Relevance 0.13 Pain Relevance 0
Inhibiting ATM kinase also worked synergistically with existing antiretroviral drugs [28].
Negative_regulation (Inhibiting) of ATM kinase associated with telangiectasia
9) Confidence 0.11 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 1.29 Pain Relevance 0
Ate tended to slightly decrease SBP, but the effect was below significance in all strains except C57BL/6J (Figure 4).
Negative_regulation (decrease) of Ate associated with sprains and strains
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.62 Pain Relevance 0
Most phenotypes were affected by (at least the highest dose of) iso with a nominal significance level of p<0.05 in at least one strain, whereas the opposite effect of ate was usually milder.
Negative_regulation (effect) of ate associated with sprains and strains
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.50 Pain Relevance 0
Three of the four lines resistant to iso responded by a significant reduction of VWI under ate (i.e.
Negative_regulation (reduction) of ate
12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.68 Pain Relevance 0

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