INT154772

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.58
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 6
lymphocytes 4
cytotoxic T lymphocytes 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 90.36 High High
Inflammation 89 89.96 High High
Arthritis 50 89.88 High High
rheumatoid arthritis 131 81.52 Quite High
fibrosis 19 74.96 Quite High
chemokine 59 73.08 Quite High
Central nervous system 2 65.24 Quite High
Biofeedback 3 47.44 Quite Low
headache 6 30.44 Quite Low
alcohol 5 22.92 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 18 98.16 Very High Very High Very High
Viral Infection 1 96.96 Very High Very High Very High
Cirrhosis 45 95.60 Very High Very High Very High
Fatigue 10 92.56 High High
Stress 118 91.20 High High
INFLAMMATION 98 89.96 High High
Juvenile Chronic Polyarthritis 40 89.88 High High
Alcoholic Liver Diseases 19 86.48 High High
Infection 26 85.04 High High
Rheumatoid Arthritis 131 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antigenic stimulation leads to massive clonal expansion of naïve CD8 T cells and to the acquisition of effector functions, including IFN-?
Positive_regulation (leads) of Localization (expansion) of CD8 in T cells
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817732 Disease Relevance 0.38 Pain Relevance 0
In our preliminary study, both aromatherapy massage and control massage decreased state anxiety significantly, and only aromatherapy massage (P < 0.05) increased PBLs, possibly due to an increase in CD8+ and CD16+ lymphocytes.
Positive_regulation (increase) of Localization (lymphocytes) of CD8 in lymphocytes associated with anxiety disorder
2) Confidence 0.21 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142199 Disease Relevance 0.42 Pain Relevance 0
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Positive_regulation (exposed) of Localization (releasing) of CD8 in lymphocytes
3) Confidence 0.17 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.38 Pain Relevance 0.19
This correlates with reports that the rapid secretion of CCL5 from memory and effector CD8+ T cells is from stored granules, which are thought to be a unique compartment, distinct from lysosomal secretory granules, and that this secretion is resistant to ER and Golgi blockade [36,37,40].
Positive_regulation (resistant) of Localization (secretion) of CD8 in T cells
4) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.39 Pain Relevance 0.23
Following the release of the entire T-cell receptor locus sequence late in 2002, we validated our assay utilizing an alternative set of TREC primers designed to minimize background signal when using PBMC DNA.


Positive_regulation (Following) of Localization (release) of T-cell receptor in T-cell
5) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.08 Pain Relevance 0.04
The 8 responders displayed a frequency of CD8+ NK responses that was about as high as half the frequency of IFN-?
Positive_regulation (frequency) of Localization (responses) of CD8
6) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.07 Pain Relevance 0
An increased number of CD8+ cytotoxic T lymphocytes and CD38 and HLA-DR activation markers have been reported, and a decrease in CD11b expression associated with an increased expression of CD28+ T subsets has been observed.
Positive_regulation (increased) of Localization (number) of CD8 in cytotoxic T lymphocytes
7) Confidence 0.06 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18801465 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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