INT154773

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.09
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
Muscle 1
paw 1
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 100.00 Very High Very High Very High
Nav1.6 12 99.92 Very High Very High Very High
Hyperalgesia 164 99.80 Very High Very High Very High
sodium channel 8 99.80 Very High Very High Very High
Nav1.7 12 99.60 Very High Very High Very High
Inflammation 455 99.58 Very High Very High Very High
nav1.8 37 99.12 Very High Very High Very High
hyperexcitability 4 98.52 Very High Very High Very High
Nav1.9 101 98.38 Very High Very High Very High
IPN 4 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 90 100.00 Very High Very High Very High
Hyperalgesia 220 99.80 Very High Very High Very High
INFLAMMATION 463 99.58 Very High Very High Very High
Targeted Disruption 54 99.56 Very High Very High Very High
Inflammatory Pain 4 96.00 Very High Very High Very High
Pain 46 95.60 Very High Very High Very High
Nociception 16 93.80 High High
Sprains And Strains 5 93.48 High High
Acidosis 17 86.16 High High
Injury 11 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of ASIC3 and sodium channels during inflammation have been documented [8-10,23-25].
Regulation (regulation) of ASIC3 associated with inflammation and sodium channel
1) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 1.38 Pain Relevance 1.55
However, real-time PCR results in our study showed no transcriptional change in ASIC3, Nav1.6, Nav1.7, and Nav1.8 mRNA level following inflammation.
Neg (no) Regulation (change) of ASIC3 associated with inflammation, nav1.8, nav1.7 and nav1.6
2) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 1.23 Pain Relevance 1.51
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Regulation (regulation) of ASIC3 in Muscle associated with inflammation
3) Confidence 0.59 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.34 Pain Relevance 0.71
Tissue underwent pathological examination and real-time PCR to reveal the gene regulation of ion channels dependent on ASIC3 following inflammation.


Regulation (regulation) of ASIC3 associated with inflammation
4) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 0.91 Pain Relevance 0.54
The up-regulation of Nav1.9 on day 2 with intraplantar carrageenan-induced inflammation was significant and ASIC3 dependent.
Regulation (dependent) of ASIC3 associated with inflammation and nav1.9
5) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 0.69 Pain Relevance 1.05
This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.
Regulation (sensitivity) of ASIC3 in paw associated with targeted disruption, inflammation and sprains and strains
6) Confidence 0.25 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18801682 Disease Relevance 0.90 Pain Relevance 0.59
However, differences were noted between the Brn3a-/- TG and published results for the Runx1 knockout for the purine receptor P2X3, which is reduced in Runx1-/- DRG but shows little change in the Brn3a-/- TG, and the acid-sensitive channel Accn3, which is increased in Runx1-/- DRG but decreased in the Brn3a knockout.
Neg (little) Regulation (change) of Accn3 associated with targeted disruption and trigeminal ganglion
7) Confidence 0.19 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.63 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox