INT154796

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.41
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (NES) intracellular (NES) molecular_function (NES)
cytoplasm (NES)
Anatomy Link Frequency
precursor cells 2
stage 3 2
stem cell 2
neural 2
NES (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 99.98 Very High Very High Very High
Nerve growth factor 1 81.24 Quite High
Dorsal horn 3 81.04 Quite High
opioid receptor 1 78.92 Quite High
Opioid 1 75.00 Quite High
Spinal cord 75 60.64 Quite High
dexamethasone 1 19.20 Low Low
GABAergic 17 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 78 91.12 High High
Suicidal Behaviour 7 89.20 High High
Cold Sores 8 88.16 High High
Rheumatoid Arthritis 17 67.72 Quite High
Glioma 24 60.56 Quite High
Glioblastoma 30 50.00 Quite Low
Disease 6 32.80 Quite Low
Malignant Neoplastic Disease 3 28.00 Quite Low
Embryonal Carcinoma 1 16.92 Low Low
Generalized Anxiety Disorder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analyses confirmed the obligatory role of these hormones; both antagonists inhibited nestin expression, an early marker of neural precursor cells normally detected during rosette formation.
Negative_regulation (inhibited) of Gene_expression (expression) of nestin in precursor cells associated with antagonist
1) Confidence 0.36 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 18803462 Disease Relevance 0 Pain Relevance 0.29
Nestin expression in grafted cells declined over the time course studied here and the greatest reduction was noted between 3 wk and 3 mo.
Negative_regulation (declined) of Gene_expression (expression) of Nestin
2) Confidence 0.30 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1796906 Disease Relevance 0 Pain Relevance 0.08
The induced cells were checked for expression of neural markers such as Nestin, ?
Negative_regulation (checked) of Gene_expression (expression) of Nestin in neural
3) Confidence 0.18 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0 Pain Relevance 0.04
In stage 3 cultures, Nestin and Ki67 expression was nearly extinguished (see Figure 2), while expression of En1, ngn3, and Hb9 increased (see Figure 1B and 1C).
Negative_regulation (extinguished) of Gene_expression (expression) of Nestin in stage 3
4) Confidence 0.15 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.42 Pain Relevance 0.03
The cells continued to show significant expression of the stem cell markers nestin and SOX2, but also of the differentiation markers GFAP and ?
Negative_regulation (show) of Gene_expression (expression) of nestin in stem cell
5) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707627 Disease Relevance 0.99 Pain Relevance 0

General Comments

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