INT154805

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.40
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 2
cleavage 1
nose 1
Polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 93.68 High High
substance P 44 79.60 Quite High
opioid receptor 2 74.76 Quite High
antagonist 5 70.52 Quite High
Potency 7 67.12 Quite High
cINOD 9 66.08 Quite High
depression 3 59.04 Quite High
Nortriptyline 1 58.44 Quite High
COX-2 inhibitor 4 51.36 Quite High
Nicotine 32 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 49 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 46 99.84 Very High Very High Very High
Apoptosis 47 99.04 Very High Very High Very High
Influenza Virus Infection 49 96.24 Very High Very High Very High
Colon Cancer 28 94.56 High High
Breast Cancer 46 93.68 High High
INFLAMMATION 41 93.68 High High
Bites And Stings 6 92.92 High High
Death 8 90.08 High High
Cancer 101 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all, 129 distinct expanded forms were extracted for the abbreviation PCR from all MEDLINE abstracts, including polymerase chain reaction, polymerization chain reaction and amplification reactions polymerized.
Gene_expression (reaction) of polymerase chain
1) Confidence 0.16 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2859134 Disease Relevance 0 Pain Relevance 0
The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DJm), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP).
Gene_expression (cleavage) of polymerase in poly
2) Confidence 0.11 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.81 Pain Relevance 0.14
Raltegravir was also >1000-fold more selective for HIV-1 integrase as compared with other phosphoryltransferases tested, including the polymerase and RNase H activities of HIV-1 reverse transcriptase and the human polymerases ?
Gene_expression (activities) of polymerase associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.61 Pain Relevance 0
We assessed point mutations in K-ras and p53 genes in tissue samples by polymerase chain reaction/single-strand conformation polymorphism and assessed expression of p53 protein by immunohistochemical methods.
Gene_expression (expression) of polymerase
4) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247607 Disease Relevance 0.47 Pain Relevance 0
M dNTPs, 2 mM MgCl2 and 0.5 units of Taq polymerase in a final volume of 25 ?
Gene_expression (dNTPs) of polymerase
5) Confidence 0.06 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2996370 Disease Relevance 0.17 Pain Relevance 0.10
Telomerase is a RNA-dependent DNA polymerase that synthesizes telomeric DNA sequences and almost universally provides the molecular basis for unlimited proliferative potential.
Gene_expression (synthesizes) of polymerase
6) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0
In this study, a single mutation, PB2 D87N, was responsible for increased G2 RNP polymerase activity at the lower temperature (33°C) found in the mammalian airway and, therefore, probably contributed to better replication in the nose, significantly elevated inflammation, or more efficient transmission.
Gene_expression (activity) of polymerase in nose associated with inflammation
7) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.31 Pain Relevance 0.05
into double-stranded DNA (dsDNA), which was then transcribed into RNA using T7 RNA polymerase (5?
Gene_expression (using) of polymerase
8) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.25
Interestingly, the polymerase activity of the RNP with PB1 from TH04 and the other proteins from WY03 was comparable to that of the wt WY03 RNP.
Gene_expression (activity) of polymerase
9) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0
In addition, Sal-B induced caspase-dependent apoptosis by cleavage of a caspase substrate, poly (ADP) ribose polymerase (PARP).
Gene_expression (ribose) of polymerase in poly associated with apoptosis
10) Confidence 0.03 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010684 Disease Relevance 0.60 Pain Relevance 0.06
Polymerase chain reaction tests for other tick-borne diseases found in this region were negative.
Neg (negative) Gene_expression (negative) of Polymerase associated with disease
11) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2396651 Disease Relevance 0.36 Pain Relevance 0
Induction of apoptosis in MDA-MB-231 cells by pamidronate was accompanied by decreased expression of the antiapoptotic protein bcl-2 as well as cleavage of poly (ADP-ribose) polymerase, thus implicating the activation of a caspase-dependent pathway.
Gene_expression (expression) of polymerase in cleavage associated with apoptosis
12) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138711 Disease Relevance 0.88 Pain Relevance 0.06
Expression under the control of the T7 promoter requires transfection in cells expressing the T7 RNA polymerase such as the BSR-T7/5 [48] or BHK/T7-9 cells [129] whereas expression from the PolI promoter is species specific so that the cells used for the study must correspond to the species of the promoter sequence [205].
Gene_expression (expressing) of polymerase
13) Confidence 0.01 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.09 Pain Relevance 0

General Comments

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