INT15481

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Context Info
Confidence 0.39
First Reported 1982
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 6.12
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plaque 3
paw 1
platelet 1
stomach 1
asa (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 254 100.00 Very High Very High Very High
Eae 6 99.46 Very High Very High Very High
Paracetamol 30 99.00 Very High Very High Very High
Enkephalin 30 98.92 Very High Very High Very High
anesthesia 34 98.58 Very High Very High Very High
ketamine 6 97.96 Very High Very High Very High
beta blocker 2 96.56 Very High Very High Very High
Calcium channel 2 95.92 Very High Very High Very High
Antinociceptive 9 94.68 High High
Pain 6 93.96 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 12 100.00 Very High Very High Very High
Wheal 1 100.00 Very High Very High Very High
Insulin Resistance 16 99.88 Very High Very High Very High
Urticaria 61 99.82 Very High Very High Very High
Inflammatory Pain 3 99.46 Very High Very High Very High
Myocardial Infarction 58 98.92 Very High Very High Very High
Fever 3 97.56 Very High Very High Very High
Hemorrhage 10 97.36 Very High Very High Very High
Stress 10 96.06 Very High Very High Very High
Hepatotoxicity 3 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twelve adult high-risk surgical patients, ASA class III-V, were induced with thiopentone and fentanyl or with infusion of ketamine.
Positive_regulation (induced) of ASA associated with ketamine
1) Confidence 0.39 Published 1982 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7113632 Disease Relevance 0 Pain Relevance 0.25
In the BCA, neither NCX 4016 nor high dose ASA influenced the number or distribution of lesions but the total plaque area was significantly increased in the ASA group (Figure 5G).
Positive_regulation (increased) of ASA in plaque associated with aspirin
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.15 Pain Relevance 0.39
Increasing ASA physical status (ASA-PS) and age significantly increased the probability of UIA.
Positive_regulation (Increasing) of ASA-PS
3) Confidence 0.28 Published 1992 Journal Anesth. Analg. Section Abstract Doc Link 1731535 Disease Relevance 0.10 Pain Relevance 0.20
Caffeine additively increases the acute antiexudative effect of ASA and aminophenazone on the carageenin-induced oedema of the hind paw of the rat.
Positive_regulation (increases) of ASA in paw associated with pressure and volume under development
4) Confidence 0.22 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.50 Pain Relevance 1.12
In contrast to the effect of aminophenazone on the inflammatory pain in the rat, the effect of ASA is not increased by caffeine and that of paracetamol only negligibly.
Neg (not) Positive_regulation (increased) of ASA associated with paracetamol and eae
5) Confidence 0.22 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.43 Pain Relevance 1.11
The ulcerogenic effect of ASA in the stomach of the rat is not increased by caffeine.
Neg (not) Positive_regulation (increased) of ASA in stomach
6) Confidence 0.22 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.46 Pain Relevance 0.96
The total plaque area of the irradiated BCA was increased after ASA, but the plaque burden was very low compared with the carotid artery.


Positive_regulation (increased) of ASA in plaque
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943480 Disease Relevance 0.24 Pain Relevance 0.10
However, the total plaque area was increased after high dose ASA (p?
Positive_regulation (increased) of ASA in plaque associated with aspirin
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.05 Pain Relevance 0.31
The antinociceptive activity of ASA in the hot-plate test was variously affected by ondansetron, ketanserin and NAN-190: at the highest dose (2 mg/kg s.c.) ondansetron abolished it while ketanserin (5 mg/kg s.c.) significantly reduced it, and NAN-190 (1-5 mg/kg) did not significantly modify the effect of ASA.
Neg (not) Positive_regulation (modify) of ASA associated with antinociceptive
9) Confidence 0.20 Published 2002 Journal Pharmacology Section Abstract Doc Link 12119448 Disease Relevance 0.09 Pain Relevance 0.41
We used four different methods to determine if Tg9949 mice suffering from neurological dysfunction had spontaneously generated prions: bioassay, neuropathology, Western blotting for rPrPSc, and ASA for sPrPSc [26].
Positive_regulation (blotting) of ASA associated with anesthesia
10) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 0.67 Pain Relevance 0.68
In fact, in a recent systematic review of almost 3000 patients undergoing ASA by Alam et al., the mean NYHA class was 2.9 (±0.01), and only 51-53% percent were on beta-blocker or calcium channel blocker therapy [2].
Positive_regulation (undergoing) of ASA associated with beta blocker and calcium channel
11) Confidence 0.05 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2780820 Disease Relevance 0.67 Pain Relevance 0.23
In the inactivation of DADME, AsA alone played the significant role.
Positive_regulation (inactivation) of AsA
12) Confidence 0.02 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506418 Disease Relevance 0 Pain Relevance 2.18
There is no good evidence to date that increasing the ASA dose would be useful, especially because of an increased risk of bleeding.99 Of note, increasing the dose of ASA is not associated with further inhibition of COX-1.99 Increasing the loading or maintenance doses of clopidogrel may be an option.25,99 Increasing the loading dose increases drug responsiveness and has been associated with improved clinical outcomes.100,101 This approach is valid only for the acute phase of treatment, however, because patients must rely on daily maintenance therapy for long-term prevention of ischemic events.
Positive_regulation (increasing) of ASA associated with hemorrhage
13) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672443 Disease Relevance 0.60 Pain Relevance 0
These may include increased oxidative stress leading to enhanced peroxidation of arachidonic acid to form biologically active isoprostanes,18 increased platelet turnover,67 increased cytosolic levels of calcium,96,97 insulin resistance, and upregulation of the P2Y12pathway.67,98

Treating ASA and clopidogrel resistance

Positive_regulation (upregulation) of ASA in platelet associated with stress and insulin resistance
14) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672443 Disease Relevance 0.76 Pain Relevance 0
Many patients with chronic urticaria exhibit increased wheal and swelling after intake of ASA (2, 8).
Positive_regulation (increased) of ASA associated with urticaria, pressure and volume under development and wheal
15) Confidence 0.01 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779320 Disease Relevance 1.40 Pain Relevance 0.30

General Comments

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