INT154869

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh4) signal transducer activity (Hrh4)
Hrh4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
Potency 1 89.52 High High
pruritus 2 84.56 Quite High
Central nervous system 1 83.20 Quite High
Opioid 1 80.52 Quite High
Neuropeptide 2 75.32 Quite High
Inflammation 1 38.24 Quite Low
Antinociceptive 1 34.56 Quite Low
Pain 2 32.16 Quite Low
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pruritus 13 98.82 Very High Very High Very High
Chronic Renal Failure 1 92.12 High High
Gallstones 1 89.48 High High
Disease 1 86.72 High High
Neuropathic Pain 1 53.44 Quite High
INFLAMMATION 1 38.24 Quite Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A series of 2-aminopyrimidines was synthesized as ligands of the histamine H4 receptor (H4R).
Gene_expression (synthesized) of histamine H4 receptor
1) Confidence 0.26 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18811133 Disease Relevance 0 Pain Relevance 0.04
Better understanding of the mediators of itch and their receptors has led to the imminent development of novel anti-itch compounds, including interleukin-31 inhibitors, histamine H4-receptor antagonists, and neurokinin-1 receptor antagonists.
Gene_expression (antagonists) of H4-receptor associated with antagonist and pruritus
2) Confidence 0.04 Published 2010 Journal Curr Allergy Asthma Rep Section Abstract Doc Link 20428977 Disease Relevance 1.33 Pain Relevance 0.34

General Comments

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