INT154886

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 29
Disease Relevance 15.51
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neurons 6
striatum 2
brain 2
cortex 2
hippocampus 2
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 3 99.80 Very High Very High Very High
Hippocampus 24 99.08 Very High Very High Very High
imagery 114 88.40 High High
projection neuron 14 85.20 High High
ketamine 26 5.00 Very Low Very Low Very Low
anesthesia 26 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 932 100.00 Very High Very High Very High
Infection 140 99.54 Very High Very High Very High
Aging 574 99.44 Very High Very High Very High
Toxicity 194 96.72 Very High Very High Very High
General Immunology 12 93.84 High High
Death 50 91.24 High High
Dementia 12 90.84 High High
Neurodegenerative Disease 108 88.00 High High
Drug Induced Neurotoxicity 28 82.28 Quite High
Targeted Disruption 112 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments, both neuropil aggregates and intranuclear inclusions can be observed in striatal neurons expressing Htt171-82Q, as previously described in rats and non-human primates [11], [14].
Gene_expression (expressing) of Htt171-82Q in neurons
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.29 Pain Relevance 0
-Gal in striatal neurons expressing Htt171-82Q may at least in part result from alterations of transcription machinery.
Gene_expression (expressing) of Htt171-82Q in neurons
2) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.55 Pain Relevance 0.04
We observed strong accumulation of mutant Htt –containing nuclear inclusions in young and old rats, suggesting that mutant Htt is expressed at relatively high levels.
Gene_expression (expressed) of mutant Htt
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.36 Pain Relevance 0.03
Interestingly, a quantitative analysis of brain sections from adult rats expressing mutant Htt shows that age affects the nature of the EM48+ aggregates.
Gene_expression (expressing) of mutant Htt in brain
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.71 Pain Relevance 0
With this antibody, the nuclei of neurons expressing mutant Htt show densely stained inclusions superimposed on diffuse staining (from light to dark staining depending on the cases) that encompasses the entire organelle.
Gene_expression (expressing) of mutant Htt in neurons
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.31 Pain Relevance 0
This suggests that mutant Htt produces a more severe dysfunction and/or degeneration in older rats.


Gene_expression (produces) of mutant Htt
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.40 Pain Relevance 0
RESULTS: During dependence state, the expression of 5-HTT mRNA in each of the regions in the high preference group was significantly lower than that of the low preference group, while higher expression of 5-HT1AR mRNA in each of the regions in the high preference group than that of the low preference group was found (P < 0.05).
Gene_expression (expression) of HTT
7) Confidence 0.65 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18812655 Disease Relevance 0 Pain Relevance 0
During withdrawal state, the expression of 5-HTT mRNA in each of the regions in high preference group was significantly higher than that of the low preference group, while lower expression of 5-HT1AR mRNA in each of the regions in the high preference group than that of the low preference group was found (P < 0.05).
Gene_expression (expression) of HTT
8) Confidence 0.65 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18812655 Disease Relevance 0 Pain Relevance 0
Htt was detected by incubating cells with mouse ?
Gene_expression (detected) of Htt
9) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.05 Pain Relevance 0.12
Htt was detected by incubating sections with mouse ?
Gene_expression (detected) of Htt
10) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.21 Pain Relevance 0.03
Association of different susceptibilities to morphine with the expression of 5-HTT and 5-HT1AR mRNA in brain regions of SD rats.
Gene_expression (expression) of HTT in brain associated with morphine
11) Confidence 0.58 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 18812655 Disease Relevance 0 Pain Relevance 0.10
-Gal expression is also the promoter that drives mutant Htt expression in the same cells in our model.
Gene_expression (expression) of mutant Htt
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.43 Pain Relevance 0.03
The reduction of DARPP-32 immunoreactivity in our HD rat model probably results from a loss of expression of DARPP-32 in dysfunctional neurons and/or an actual loss of striatal neurons.
Gene_expression (model) of HD in neurons associated with disease
13) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.90 Pain Relevance 0.04
-Gal phenotype was uniquely produced by transcription inhibition, mutant Htt expression would be markedly down-regulated as well, so that build up of inclusion/aggregates could not be detected.
Gene_expression (expression) of mutant Htt
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.30 Pain Relevance 0
In line with this, neuroprotective strategies not directly targeting transcription (e.g. chaperones and calcineurin) block the loss of DARPP32 produced by mutant Htt in our rat model [12], [13], [61].
Gene_expression (produced) of mutant Htt
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.20 Pain Relevance 0
The ubiquitous expression of Htt does not provide an explanation for the selective striatal cell neurodegeneration at the onset of HD.
Gene_expression (expression) of Htt associated with disease
16) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.89 Pain Relevance 0.04
The combinatorial approach including multicolor FISH/IFS and associated co-localization analysis indicates that Htt and dynein can be found in close proximity to BDNF mRNA.


Gene_expression (found) of Htt
17) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.43 Pain Relevance 0
Huntington's disease (HD) protein huntingtin (Htt) is a 350 kDa protein widely expressed at high levels in the hippocampus, cortex, cerebellum and striatum.
Gene_expression (expressed) of Htt in cerebellum associated with hippocampus and disease
18) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.57 Pain Relevance 0.05
Huntington's disease (HD) protein huntingtin (Htt) is a 350 kDa protein widely expressed at high levels in the hippocampus, cortex, cerebellum and striatum.
Gene_expression (expressed) of huntingtin in cerebellum associated with hippocampus and disease
19) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.57 Pain Relevance 0.05
Histological evaluation at different time points after infection demonstrated that the expression of mutant Htt led to pathological changes that were more severe in old rats, including an increase in the number of small Htt-containing aggregates in the neuropil, a greater loss of DARPP-32 immunoreactivity and striatal neurons as assessed by unbiased stereological counts.
Gene_expression (expression) of mutant Htt in neurons associated with infection
20) Confidence 0.52 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2645678 Disease Relevance 1.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox