INT15489

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.78
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
chondrocytes 2
osteoblasts 2
spinal cord 2
Oocytes 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Botox 5 100.00 Very High Very High Very High
tramadol 9 99.96 Very High Very High Very High
endometriosis 6 99.88 Very High Very High Very High
withdrawal 1 99.86 Very High Very High Very High
Neurotransmitter 3 99.00 Very High Very High Very High
Spinal cord 4 98.84 Very High Very High Very High
Analgesic 2 97.52 Very High Very High Very High
Pain 3 96.80 Very High Very High Very High
antinociception 1 95.52 Very High Very High Very High
cINOD 3 94.48 High High
Disease Link Frequency Relevance Heat
Spasticity 5 99.96 Very High Very High Very High
Endometriosis 7 99.88 Very High Very High Very High
Stroke 6 99.20 Very High Very High Very High
Osteoporosis 2 97.00 Very High Very High Very High
Pain 3 96.80 Very High Very High Very High
Blister 5 94.20 High High
Osteogenesis Imperfecta 5 93.76 High High
Pancreatic Cancer 3 91.96 High High
Muscular Spasm 1 90.80 High High
Bullous Skin Disease 2 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes.
Negative_regulation (inhibits) of Gene_expression (expressed) of type in Oocytes associated with tramadol
1) Confidence 0.42 Published 2006 Journal Pharmacology Section Title Doc Link 16679816 Disease Relevance 0.08 Pain Relevance 1.10
The biosynthesis of type II collagen was suppressed to 70% to 80% of the control by indomethacin and ASA.
Negative_regulation (suppressed) of Gene_expression (biosynthesis) of type
2) Confidence 0.42 Published 1989 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2734619 Disease Relevance 0.07 Pain Relevance 0.27
This pattern of reduced bone formation is suggestive of defective production of collagen type I.
Negative_regulation (defective) of Gene_expression (production) of type
3) Confidence 0.42 Published 2003 Journal Vet. Pathol. Section Abstract Doc Link 12949410 Disease Relevance 0.53 Pain Relevance 0
The mRNA expressions of type II collagen, aggrecan, and type X collagen in chondrocytes were decreased significantly by the co-culture with osteoblasts pre-treated by IL-1beta, -6, and TNF-alpha.
Negative_regulation (decreased) of Gene_expression (expressions) of type in chondrocytes
4) Confidence 0.42 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.39
After MG132 withdrawal, wild-type HPK1 protein expression was markedly decreased within 24 hours, but kinase-dead HPK1 mutant protein expression was sustained for up to 96 hours.
Negative_regulation (decreased) of Gene_expression (expression) of type associated with withdrawal
5) Confidence 0.41 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19141650 Disease Relevance 0.85 Pain Relevance 0.13
Although several papers have shown that intramuscular injections of botulinum toxin type A (BT-A) decreases spasticity in post-stroke patients, few authors have demonstrated functional improvement after this therapy.
Negative_regulation (decreases) of Gene_expression (injections) of type associated with spasticity, stroke and botox
6) Confidence 0.41 Published 2007 Journal Arq Neuropsiquiatr Section Abstract Doc Link 17876396 Disease Relevance 1.19 Pain Relevance 0.27
The expression of the wild-type SPINK1 transcript was decreased to 62% of the healthy control in the CP patient carrying the heterozygous [-215G>A; IVS3+2T>C] mutation.
Negative_regulation (decreased) of Gene_expression (expression) of type
7) Confidence 0.41 Published 2007 Journal Pancreas Section Body Doc Link 17446841 Disease Relevance 0 Pain Relevance 0
This method was used for assessing type I and type III collagen synthesis after topical glucocorticoid treatment.
Negative_regulation (assessing) of Gene_expression (synthesis) of type
8) Confidence 0.41 Published 1992 Journal J. Invest. Dermatol. Section Abstract Doc Link 1732386 Disease Relevance 0.68 Pain Relevance 0.05
Another abnormality in endometriosis, the deficient 17beta-hydroxysteroiddehydrogenase type II (17beta-HSD-Type-II) expression, impairs the inactivation of estradiol to estrone.
Negative_regulation (deficient) of Gene_expression (expression) of type associated with endometriosis
9) Confidence 0.41 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 16157442 Disease Relevance 0.70 Pain Relevance 0.30
RT-PCR studies showed the expression of N- and P/Q-type channel mRNAs in the turtle spinal cord.
Negative_regulation (showed) of Gene_expression (expression) of type in spinal cord associated with spinal cord
10) Confidence 0.41 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15063793 Disease Relevance 0 Pain Relevance 0.41
We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone.
Negative_regulation (decrease) of Gene_expression (expressions) of type in osteoblasts
11) Confidence 0.41 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.33 Pain Relevance 0.26

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