INT15490

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 25.97
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
fibroblasts 23
chondrocytes 4
cartilage 4
lung 3
platelets 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 30 99.96 Very High Very High Very High
aspirin 24 99.78 Very High Very High Very High
cINOD 60 99.52 Very High Very High Very High
Osteoarthritis 236 99.46 Very High Very High Very High
corticosteroid 41 99.14 Very High Very High Very High
adenocard 71 98.80 Very High Very High Very High
Inflammatory response 26 98.74 Very High Very High Very High
agonist 66 96.76 Very High Very High Very High
cytokine 118 96.44 Very High Very High Very High
Inflammation 166 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 6 100.00 Very High Very High Very High
Infection 44 99.88 Very High Very High Very High
Keloid Scars 54 99.84 Very High Very High Very High
Osteoarthritis 246 99.46 Very High Very High Very High
Injury 461 99.44 Very High Very High Very High
Stress 68 99.44 Very High Very High Very High
Disease 124 99.28 Very High Very High Very High
INFLAMMATION 231 99.24 Very High Very High Very High
Mixed Connective Tissue Disorder 1 98.82 Very High Very High Very High
Wound Healing 452 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ascorbate is essential for collagen production, and vitamin C deficiency will result in defective connective tissue, including reductions in collagen synthesis and structural stability.
Negative_regulation (reductions) of Gene_expression (synthesis) of collagen in connective tissue
1) Confidence 0.58 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19932568 Disease Relevance 1.03 Pain Relevance 0.10
A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment.
Negative_regulation (decreased) of Gene_expression (synthesis) of collagen in skin
2) Confidence 0.51 Published 1992 Journal J. Invest. Dermatol. Section Title Doc Link 1732386 Disease Relevance 0.57 Pain Relevance 0
Acetylsalicylic acid-dependent inhibition of collagen biosynthesis and beta1-integrin signaling in cultured fibroblasts.
Negative_regulation (inhibition) of Gene_expression (biosynthesis) of collagen in fibroblasts associated with aspirin
3) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Title Doc Link 15173663 Disease Relevance 0.10 Pain Relevance 0.33
To discover whether this is an underlying mechanism of acetylsalicylic acid-dependent inhibition of collagen biosynthesis in fibroblasts was the aim of this study.
Negative_regulation (inhibition) of Gene_expression (biosynthesis) of collagen in fibroblasts associated with aspirin
4) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.08 Pain Relevance 0.24
A decrease in collagen biosynthesis decreases the interaction of the protein with the b1-integrin receptor (extracellular process), disturbing signaling (intracellular process).
Negative_regulation (decrease) of Gene_expression (biosynthesis) of collagen
5) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Non-steroid anti-inflammatory drugs (NSAIDs) are known inhibitors of collagen biosynthesis in animal tissues and cell cultures.
Negative_regulation (inhibitors) of Gene_expression (biosynthesis) of collagen in animal tissues associated with inflammation and cinod
6) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.10 Pain Relevance 0.27
This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.
Negative_regulation (decrease) of Gene_expression (biosynthesis) of collagen
7) Confidence 0.36 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Prostaglandin E1 inhibited collagen production in both types of FIB, but nonsteroidal anti-inflammatory drugs and interleukin-1beta, a cytokine involved in the wound-healing process, had opposite effects on gastric and skin FIB.
Negative_regulation (inhibited) of Gene_expression (production) of collagen in FIB associated with inflammation, injury, cinod and cytokine
8) Confidence 0.36 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.35 Pain Relevance 0.15
Recent studies have shown the inhibitory effect of interferons on dermal fibroblast growth and/or collagen production.
Negative_regulation (effect) of Gene_expression (production) of collagen in fibroblast
9) Confidence 0.33 Published 1996 Journal Int. J. Dermatol. Section Abstract Doc Link 8809610 Disease Relevance 0.65 Pain Relevance 0
Such complications include wound dehiscence, infection, and impaired collagen synthesis.
Negative_regulation (impaired) of Gene_expression (synthesis) of collagen in dehiscence associated with injury and infection
10) Confidence 0.30 Published 2005 Journal Pharmacotherapy Section Abstract Doc Link 16232020 Disease Relevance 1.28 Pain Relevance 0.29
In the vitamin C–deficient group, the abscesses formed were much larger than those in the control group, which was attributed to impaired collagen production in the test animals, leading to inadequate sequestration or “walling off” of the bacteria.139 Neutrophils are also affected in vitamin C deficiency: as vitamin C is required to reduce oxygen to superoxide, free radical production is decreased and neutrophil function is impaired.2
Negative_regulation (impaired) of Gene_expression (production) of collagen in neutrophil associated with abscess
11) Confidence 0.29 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.95 Pain Relevance 0
By comparison with keloid and hypertrophic scars, it is natural to presume that tranilast should inhibit collagen synthesis and the proliferation of fibroblasts in desmoid tumor, leading to shrinkage of the tumor.
Negative_regulation (inhibit) of Gene_expression (synthesis) of collagen in fibroblasts associated with cancer, desmoid disease and keloid scars
12) Confidence 0.28 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2999613 Disease Relevance 1.56 Pain Relevance 0.03
CONCLUSIONS: The inhibitory effect of acetylsalicylic acid on collagen biosynthesis in fibroblasts is coupled to the inhibition of prolidase phosphorylation (but not expression) and down-regulation of the intracellular signal transmitted by the b1-integrin receptor.


Negative_regulation (effect) of Gene_expression (biosynthesis) of collagen in fibroblasts
13) Confidence 0.27 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
RESULTS: In cells treated with acetylsalicylic acid, a concomitant decrease in prolidase activity, prolidase phosphorylation (at the threonine residue), and collagen biosynthesis were observed.
Negative_regulation (decrease) of Gene_expression (biosynthesis) of collagen
14) Confidence 0.26 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Bleomycin limits skin fibroblast production of collagen, which helps account for its ability to impede wound healing.78 This effect was noted when 30 mg/kg of bleomycin administered postoperatively demonstrated decreased wound tensile strength, most noticeably around postoperative day 7, although similar findings were not evident 3 or 21 days postoperatively.42 This appears to be a dose-dependent and timing-related relationship, as bleomycin's negative effects on wound healing also decreased from the time of administration of the agent.79 Minimal changes are elicited when intralesional bleomycin is employed, and there is little evidence for morbidity associated with intracavitary bleomycin as well.80,81 While animal studies suggest that bleomycin may impair wound healing when dosed preoperatively or at the time of surgery, these effects may not be clinically significant by 3 weeks postoperatively.
Negative_regulation (limits) of Gene_expression (production) of collagen in fibroblast associated with injury and wound healing
15) Confidence 0.21 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 1.01 Pain Relevance 0.13
This may be attributed to the ability of vitamin A to reverse some of the stabilizing effects of corticosteroids on lysosomal membranes, thereby restoring an active component of the inflammatory response.141,142 Doses of 25,000 IU/oz applied topically to wounds daily have been shown to have some local benefit without compromising the systemic effects of corticosteroid therapy.143 Vitamin A deficiency leads to decreased collagen synthesis and cross-linking, decreased epithelialization, and slower rate of wound closure.144 Patients with severe injuries, malabsorption, or malnutrition are at risk of vitamin A deficiency and should receive dietary supplement of 25,000 IU/day of vitamin A.2
Negative_regulation (decreased) of Gene_expression (synthesis) of collagen associated with appetite loss, inflammatory response, corticosteroid and injury
16) Confidence 0.21 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 1.07 Pain Relevance 0.26
Although this may implicate vitamin E as being counterproductive to wound repair, several studies suggest that vitamin E is beneficial to wound healing.145 For example, rats fed on a vitamin E–deficient diet have impaired collagen synthesis, which implies that vitamin E may be an important cofactor in collagen cross-linking and polymerization.146 In another investigation, vitamin E was found to have inhibitory effects on hyaluronidase activity in humans, which suggests a beneficial role in extracellular matrix deposition.147 Although the contributions of vitamin E are not clearly defined, it is likely that it contributes toward the wound healing process.
Negative_regulation (impaired) of Gene_expression (synthesis) of collagen in extracellular matrix associated with wound healing and injury
17) Confidence 0.21 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.83 Pain Relevance 0.19
Tranilast suppresses collagen synthesis in keloid or hypertrophic scars, which is mediated by inhibiting the release of TGF-?
Negative_regulation (suppresses) of Gene_expression (synthesis) of collagen associated with keloid scars
18) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2999613 Disease Relevance 1.75 Pain Relevance 0.13
Thus, the inhibitory mechanism of keloid or hypertrophic scar formation by tranilast is achieved by suppressing the proliferation of fibroblasts and by inhibiting collagen synthesis.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of collagen in fibroblasts associated with keloid scars
19) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2999613 Disease Relevance 1.85 Pain Relevance 0.03
FOY-007 attenuated the collagen synthesis and PIP production stimulated by TGF-beta1 dose dependently, but FOY-305 inhibited only PIP production.
Negative_regulation (attenuated) of Gene_expression (synthesis) of collagen
20) Confidence 0.20 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.13 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox