INT154969

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.42
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
spinal cord 2
pores 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 2 98.64 Very High Very High Very High
Spinal cord 2 97.44 Very High Very High Very High
Pain 11 96.00 Very High Very High Very High
Immobilon 1 95.40 Very High Very High Very High
IPN 1 85.44 High High
ischemia 33 75.08 Quite High
Lasting pain 1 73.56 Quite High
cINOD 1 69.52 Quite High
COX2 2 25.00 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 98.92 Very High Very High Very High
Apoptosis 74 96.32 Very High Very High Very High
Pain 10 96.00 Very High Very High Very High
Death 15 95.12 Very High Very High Very High
Inflammatory Pain 1 85.44 High High
Hepatotoxicity- Drug-induced 1 76.08 Quite High
Cv Unclassified Under Development 11 75.08 Quite High
Pressure And Volume Under Development 1 71.60 Quite High
Hepatotoxicity 1 71.48 Quite High
INFLAMMATION 1 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nimesulide exposure increased intracellular ROS, translocation of Bax and Bcl2 followed by mitochondrial depolarization and cytochrome c (Cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis.
Positive_regulation (increased) of Localization (translocation) of Bax associated with apoptosis
1) Confidence 0.64 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19772912 Disease Relevance 0.75 Pain Relevance 0.07
These results showed an increased ratio of Bax/Bcl-2 and activated caspase-3 in hippocampus and dorsal lumbar spinal cord of animals treated with pain and IMO stress; these effects were reduced in ADX animals.
Positive_regulation (increased) of Localization (ratio) of Bax in spinal cord associated with stress, pain, hippocampus and spinal cord
2) Confidence 0.50 Published 2008 Journal Neuroscience Section Abstract Doc Link 18822355 Disease Relevance 1.75 Pain Relevance 1.05
When stimulated, Bax is activated and translocated to the mitochondria, where it forms pores in the outer membrane by binding with the adenine nucleotide translocator leading to permeabilization of the mitochondria [11-13].
Positive_regulation (activated) of Localization (translocated) of Bax in pores
3) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.76 Pain Relevance 0.10
After blockade of non-specific binding sites, membranes were incubated for 2 h at room temperature with a mouse monoclonal anti-Bcl-xL (1:1,000; BD PharMingen, Heidelberg, Germany) or a mouse monoclonal anti-Bax antibody (1:250; BD PharMingen), followed by a secondary peroxidase-linked anti-mouse antibody (BcL-xL 1:10,000 and Bax 1:20,000; Sigma).
Positive_regulation (incubated) of Localization (secondary) of Bax
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.16 Pain Relevance 0.05

General Comments

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