INT155

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Context Info
Confidence 0.70
First Reported 1970
Last Reported 2010
Negated 53
Speculated 33
Reported most in Abstract
Documents 1233
Total Number 1266
Disease Relevance 317.93
Pain Relevance 457.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 230
pituitary 57
blood 33
body 16
thyroid 16
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1767 100.00 Very High Very High Very High
narcan 1295 100.00 Very High Very High Very High
Morphine 982 100.00 Very High Very High Very High
depression 918 100.00 Very High Very High Very High
fluoxetine 905 100.00 Very High Very High Very High
Opioid 612 100.00 Very High Very High Very High
anesthesia 408 100.00 Very High Very High Very High
Enkephalin 386 100.00 Very High Very High Very High
headache 264 100.00 Very High Very High Very High
Somatostatin 197 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2422 100.00 Very High Very High Very High
Depression 1226 100.00 Very High Very High Very High
Cancer 1008 100.00 Very High Very High Very High
Galactorrhea 663 100.00 Very High Very High Very High
Headache 301 100.00 Very High Very High Very High
Sleep Disorders 301 100.00 Very High Very High Very High
Reprotox - General 1 287 100.00 Very High Very High Very High
Syndrome 219 100.00 Very High Very High Very High
Adenoma 204 100.00 Very High Very High Very High
Body Weight 175 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, elevation of Prl levels during mating is not necessary to normal sexual behavior in the intact male rat.
Positive_regulation (elevation) of Prl
1) Confidence 0.70 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 440533 Disease Relevance 0.17 Pain Relevance 0.16
When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically elevated.
Positive_regulation (elevated) of prolactin in plasma
2) Confidence 0.70 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 683470 Disease Relevance 0 Pain Relevance 0.10
When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically elevated.
Positive_regulation (elevated) of Prl in plasma
3) Confidence 0.70 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 683470 Disease Relevance 0 Pain Relevance 0.10
Morphine increased the serum prolactin (PRL) levels of male rats in a dose response manner.
Positive_regulation (increased) of PRL associated with morphine
4) Confidence 0.70 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 745306 Disease Relevance 0 Pain Relevance 0.73
Morphine increased the serum prolactin (PRL) levels of male rats in a dose response manner.
Positive_regulation (increased) of prolactin associated with morphine
5) Confidence 0.70 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 745306 Disease Relevance 0 Pain Relevance 0.73
Injection of either thyrotropin-releasing hormone (TRH; 10 micrograms/kg) or pimozide (0.5 mg/kg) elevated serum PRL concentrations similarly in lactating and nonlactating rats when examined just before the beginning of the expected estrogen-induced PRL surge.
Positive_regulation (elevated) of PRL
6) Confidence 0.70 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.19 Pain Relevance 0
Injection of either thyrotropin-releasing hormone (TRH; 10 micrograms/kg) or pimozide (0.5 mg/kg) elevated serum PRL concentrations similarly in lactating and nonlactating rats when examined just before the beginning of the expected estrogen-induced PRL surge.
Positive_regulation (induced) of PRL
7) Confidence 0.70 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.19 Pain Relevance 0.06
Intravenous injection of 5 mg/kg morphine did not change plasma PRL levels in the sham-operated lactating rats, but it resulted in a significant increase of plasma PRL levels in ADX lactating animals, with or without corticosterone replacement.
Positive_regulation (increase) of PRL in plasma associated with morphine
8) Confidence 0.70 Published 1991 Journal Brain Res. Section Abstract Doc Link 1786530 Disease Relevance 0.09 Pain Relevance 0.66
Morphine given 2 h after haloperidol treatment resulted in a further increase of plasma PRL in ADX, but not in the sham-operated lactating animals.
Neg (not) Positive_regulation (increase) of PRL in plasma associated with morphine
9) Confidence 0.70 Published 1991 Journal Brain Res. Section Abstract Doc Link 1786530 Disease Relevance 0.09 Pain Relevance 0.65
In addition, the increase in serum PRL concentrations induced by restraint stress was attenuated greatly in rats treated 4 hr earlier with morphine.
Positive_regulation (induced) of PRL associated with stress and morphine
10) Confidence 0.70 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.19 Pain Relevance 0.80
A single injection of morphine also resulted 4 hr later in an attenuation of the PRL response to a second injection of morphine (7.5 mg/kg); however, the increase in serum PRL concentration produced by alpha-methyltyrosine (250 mg/kg) was unaltered by prior morphine administration.
Positive_regulation (increase) of PRL associated with morphine
11) Confidence 0.70 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.17 Pain Relevance 1.33
On the contrary, 1 microgram/kg of dermorphin significantly elevates Prl concentrations 10 min after injection, leaving serum Prl levels unchanged 30 and 60 min after the administration.
Positive_regulation (elevates) of Prl
12) Confidence 0.70 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.07 Pain Relevance 0.31
In vivo experiments: subcutaneous administrations of different doses of dermorphin ranging from 0.1 to 5 mg/kg body weight to normal male rats induce a statistically significant, dose-related increase in serum Prl levels.
Positive_regulation (increase) of Prl in body associated with body weight
13) Confidence 0.70 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.10 Pain Relevance 0.28
In orchidectomized (3 weeks) rats, the intraventricular administration of dermorphin at the dose of 0.25 micrograms/kg appears effective in enhancing Prl levels only 30 min after treatment.
Spec (appears) Positive_regulation (enhancing) of Prl
14) Confidence 0.70 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0 Pain Relevance 0.19
On the contrary, 1 microgram/kg of dermorphin significantly elevates Prl concentrations 10 min after injection, leaving serum Prl levels unchanged 30 and 60 min after the administration.
Neg (unchanged) Positive_regulation (unchanged) of Prl
15) Confidence 0.70 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.07 Pain Relevance 0.31
ICV injection of atropine sulfate (250 micrograms/rat) also inhibited the occurrence of the nocturnal PRL surge when given at 0000 h on Day 3, though a slight and transient elevation of plasma PRL levels were seen.
Positive_regulation (elevation) of PRL in plasma associated with intracerebroventricular
16) Confidence 0.70 Published 1983 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 6617924 Disease Relevance 0.06 Pain Relevance 0.26
Pinching the hindpaw for 6 min significantly increased plasma PRL concentration during stimulation to about 280% of the prestimulation value (p < 0.05).
Positive_regulation (increased) of PRL in plasma
17) Confidence 0.70 Published 1993 Journal Jpn. J. Physiol. Section Abstract Doc Link 8114360 Disease Relevance 0.08 Pain Relevance 0.06
Surgical stress induced a 204% increase of plasma PRL at 5 min in the control group, but failed to induce alterations of PRL in the hyperprolactinemic group.
Positive_regulation (increase) of PRL in plasma associated with stress
18) Confidence 0.70 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.74 Pain Relevance 0.08
Restraint stress induced a marked increase of plasma PRL of control rats with a peak at 15 min (increase of 403%), but did not change the PRL levels of hyperprolactinemic rats.
Positive_regulation (increase) of PRL in plasma associated with stress
19) Confidence 0.70 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.60 Pain Relevance 0.09
The sham-operated rats presented a three-fold increase of PRL levels as early as after 5 min of surgical stress (P < 0.01); the PRL levels reached a peak at about 15 min and returned to baseline at 40 min.
Positive_regulation (increase) of PRL associated with stress
20) Confidence 0.70 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9070395 Disease Relevance 0.43 Pain Relevance 0.09

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