INT155009

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A, IL17A) extracellular space (IL17A) cell death (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
Th17 cells 2
naive T cells 2
IL23A (Homo sapiens)
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 3 96.16 Very High Very High Very High
Inflammation 7 80.60 Quite High
psoriasis 61 69.84 Quite High
cytokine 5 64.40 Quite High
Arthritis 22 41.12 Quite Low
chemokine 1 37.44 Quite Low
Osteoarthritis 1 25.00 Low Low
depression 1 6.68 Low Low
withdrawal 8 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 24 96.16 Very High Very High Very High
Psoriasis 69 84.96 Quite High
INFLAMMATION 6 80.60 Quite High
Autoimmune Disease 1 52.80 Quite High
Disease 15 46.32 Quite Low
Arthritis 3 41.12 Quite Low
Osteoarthritis 1 25.00 Low Low
Cancer 2 13.28 Low Low
Heart Disease 1 12.96 Low Low
Affective Disorder 1 8.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-23 is the main inductor in Th17 polarization of naive T cells, inducing IL-17 production.
IL-23 Positive_regulation (inducing) of Gene_expression (production) of IL-17 in naive T cells
1) Confidence 0.17 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.19 Pain Relevance 0.19
In turn, IL-23 sustains Th17 proliferation, hence primarily increasing levels of IL-17 and IL-22 produced by these activated Th17 cells (It has been suggested that Th0 differentiation into Th17 is originally initiated by IL-6 and TGF-?
IL-23 Positive_regulation (increasing) of Gene_expression (levels) of IL-17 in Th17 cells
2) Confidence 0.11 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.43 Pain Relevance 0.20

General Comments

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