INT155010

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 20.17
Pain Relevance 7.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A) cell death (IL17A) extracellular region (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
T-lymphocytes 6
lung 4
synovial fluid 2
naive T cells 2
joints 2
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 430 100.00 Very High Very High Very High
Osteoarthritis 123 100.00 Very High Very High Very High
Central nervous system 42 100.00 Very High Very High Very High
Arthritis 418 99.68 Very High Very High Very High
Inflammation 596 99.52 Very High Very High Very High
rheumatoid arthritis 311 99.44 Very High Very High Very High
chemokine 61 99.08 Very High Very High Very High
spinal inflammation 6 96.16 Very High Very High Very High
metalloproteinase 46 93.44 High High
Leflunomide 22 92.36 High High
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 67 100.00 Very High Very High Very High
Vasculitis 60 99.88 Very High Very High Very High
Keloid Scars 722 99.84 Very High Very High Very High
Rheumatoid Arthritis 731 99.68 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 222 99.56 Very High Very High Very High
INFLAMMATION 647 99.52 Very High Very High Very High
Arthritis 24 99.00 Very High Very High Very High
Disease 498 98.98 Very High Very High Very High
Dengue Hemorrhagic Fever 12 98.64 Very High Very High Very High
Osteoarthritis 25 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone and synovial explants from RA joints exhibit increased production of functional IL-17 compared to OA joints [10], and IL-17+ CD4+ T cells can be found in RA synovial tissue [11], [12].
Positive_regulation (increased) of Gene_expression (production) of IL-17 in joints associated with arthritis
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 1.14 Pain Relevance 0.77
A role for IL-17 in angiogenesis is supported by the recent findings that local overexpression of IL-17 in C57BL/6 mice induces arthritis with increased vascularity, and that IL-17 induces migration of endothelial cells in vitro, along with increased angiogenesis in Matrigel plugs [34].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-17 in endothelial cells associated with arthritis
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.81 Pain Relevance 0.35
In addition, we have previously proposed a mechanism for generation of Th17 cells in the joint itself, as cell contact with in vitro (LPS) activated [36] or in vivo activated monocytes from inflamed joints from RA patients [11] leads to induction of IL-17 production in memory CD4+ T cells, suggesting that newly recruited CD4+ T cells can be skewed toward a Th17 phenotype at the site of inflammation.
Positive_regulation (induction) of Gene_expression (production) of IL-17 in Th17 cells associated with inflammation and arthritis
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.65 Pain Relevance 0.26
Through their production of IL-17 and TNF?
Positive_regulation (their) of Gene_expression (production) of IL-17
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.84 Pain Relevance 0.35
In addition, we demonstrate that IL-17 and TNF?
Positive_regulation (demonstrate) of Gene_expression (demonstrate) of IL-17
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.84 Pain Relevance 0.35
In the current study, we determined whether mRNA for IL-17A is elevated and protein expression of IL-17A occurs locally in inflammatory cells within the human bronchoalveolar space during severe inflammation caused by organic dust.
Spec (whether) Positive_regulation (occurs) of Gene_expression (expression) of IL-17A associated with inflammation
6) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.33 Pain Relevance 0.17
IL-23 is the main inductor in Th17 polarization of naive T cells, inducing IL-17 production.
Positive_regulation (inducing) of Gene_expression (production) of IL-17 in naive T cells
7) Confidence 0.31 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.19 Pain Relevance 0.19
A robust elevation of IL-6 and IL-17 expression in keloid is confirmed by cytokine array, western blot and ELISA analyses.
Positive_regulation (elevation) of Gene_expression (expression) of IL-17 associated with keloid scars and cytokine
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2771422 Disease Relevance 1.16 Pain Relevance 0.21
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL17 in lung associated with chemokine and cytokine
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL17 in lung associated with chemokine and cytokine
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Our results showed that incubation with IL-17 enhanced IL-6 expression in both SKPs and KPCs (Figure 5A).
Positive_regulation (enhanced) of Gene_expression (expression) of IL-17
11) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.10 Pain Relevance 0
The increased expression of IL-17 in keloid tissues was discernible around T-cell receptor CD3-positive cells as determined by dual-color immunofluorescence staining (Figure 3D).
Positive_regulation (increased) of Gene_expression (expression) of IL-17 in T-cell associated with keloid scars
12) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.58 Pain Relevance 0.18
Herein, we observed an elevated expression of IL-17R in KPCs as compared to SKPs (Figure 3I; Figure S4C).
Positive_regulation (elevated) of Gene_expression (expression) of IL-17R
13) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.64 Pain Relevance 0.15
IL-17/IL-6 axis contributes to the fibroproliferative growth of KPCs-generated transplants
Positive_regulation (contributes) of Gene_expression (axis) of IL-17
14) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.26 Pain Relevance 0.04
Immunofluorescence studies showed an increased expression of IL-17 by CD4 positive-T-lymphocytes, which was further enhanced by IL-6 treatment (Figure 7B).
Positive_regulation (increased) of Gene_expression (expression) of IL-17 in T-lymphocytes
15) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.22 Pain Relevance 0
The increased IL-17 expression was further confirmed by ELISA assay (Figure 7C).
Positive_regulation (increased) of Gene_expression (expression) of IL-17
16) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.23 Pain Relevance 0
RA synovial explants spontaneously produce IL-17 [2] and increased levels of IL-17 are found in RA synovial fluid (SF) compared with osteoarthritis (OA) SF [3].
Positive_regulation (increased) of Gene_expression (levels) of IL-17 in synovial fluid associated with rheumatoid arthritis and osteoarthritis
17) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.11 Pain Relevance 0.65
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Positive_regulation (as) of Gene_expression (production) of IL-17 associated with central nervous system and cytokine
18) Confidence 0.12 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.52 Pain Relevance 0.31
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Positive_regulation (enhances) of Gene_expression (production) of IL-17 associated with central nervous system and cytokine
19) Confidence 0.12 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.55 Pain Relevance 0.31
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Positive_regulation (activation) of Gene_expression (production) of IL-17 associated with central nervous system and cytokine
20) Confidence 0.12 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.54 Pain Relevance 0.31

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