INT155011

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.43
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A) cell death (IL17A) extracellular region (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
lymphocyte 1
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 163 99.96 Very High Very High Very High
Arthritis 139 99.82 Very High Very High Very High
rheumatoid arthritis 168 99.04 Very High Very High Very High
spinal inflammation 3 98.56 Very High Very High Very High
antagonist 6 96.22 Very High Very High Very High
Inflammation 171 94.88 High High
methotrexate 47 92.24 High High
corticosteroid 12 91.60 High High
Osteoarthritis 32 75.28 Quite High
metalloproteinase 9 72.88 Quite High
Disease Link Frequency Relevance Heat
Arthritis 72 99.82 Very High Very High Very High
Rheumatoid Arthritis 243 99.56 Very High Very High Very High
Seronegative Spondarthritis 5 98.56 Very High Very High Very High
Disease 140 97.40 Very High Very High Very High
INFLAMMATION 196 94.88 High High
Keloid Scars 206 91.20 High High
Infection 16 90.92 High High
Hypersensitivity 4 86.00 High High
Fever 80 85.88 High High
Synovitis 17 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly, recent clinical trials with IL-17 antagonists in established RA show up to 42% ACR50 responses with short duration therapy [14], providing the first direct evidence in humans of a pathological role of IL-17 in RA, and indicating that blockade of IL-17 in humans may be a valid therapeutic approach.
Negative_regulation (blockade) of IL-17 associated with antagonist and arthritis
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.94 Pain Relevance 0.70
In addition, the data establish IL-8 and IL-17A as other potential therapeutic targets at an early stage of the disease.
Negative_regulation (establish) of IL-17A associated with disease
2) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.19 Pain Relevance 1.01
The lymphocyte-specific cytokine, IL7, and CD4+ T-helper cytokine, IL17, were suppressed in both AFP and FP sera compared to controls (Figure 4A and Additional File 4, Table S3).
Negative_regulation (suppressed) of IL17 in lymphocyte associated with cytokine
3) Confidence 0.30 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.58 Pain Relevance 0.53
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Negative_regulation (levels) of IL 17
4) Confidence 0.26 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.52 Pain Relevance 0.29
Furthermore, we demonstrated that blocking IL-6 abolished IL-17-induced up-regulation of hTERT and Oct-4 expression; however, blocking IL-17 failed to attenuate IL-6-induced up-regulation of hTERT and Oct-4 expression in KPCs.
Negative_regulation (blocking) of IL-17
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.16 Pain Relevance 0.20
Our results indicated that IL-17-induced hTERT and Oct-4 expression was abolished by pretreatment with neutralizing antibody for either IL-17, or IL-6, or both (Figure 5D).
Negative_regulation (abolished) of IL-17-induced
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.07 Pain Relevance 0
Since the development of arthritis can be inhibited by blocking IL-17, Th17 plays a crucial role in arthritis models (Lubberts et al 2004).
Negative_regulation (blocking) of IL-17 associated with arthritis
7) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.93 Pain Relevance 0.39
A recent study testing a possible immunomodulatory activity of GTE in arthritis showed that GTE administration in drinking water ameliorated rat adjuvant-induced arthritis via the inhibition of serum IL-17 levels, with a concomitant upregulation of serum IL-10 levels [52].
Negative_regulation (inhibition) of IL-17 associated with arthritis
8) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.03 Pain Relevance 0.53

General Comments

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