INT155012

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 8.64
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A) cell death (IL17A) extracellular region (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
T cells 8
lymph node 3
lymphocytes 3
epithelium 2
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 183 100.00 Very High Very High Very High
spinal inflammation 4 98.56 Very High Very High Very High
Inflammation 370 93.44 High High
Leflunomide 15 92.08 High High
metalloproteinase 23 86.32 High High
Arthritis 44 81.60 Quite High
rheumatoid arthritis 116 79.04 Quite High
Inflammatory mediators 14 78.80 Quite High
Osteoarthritis 33 75.28 Quite High
Pain 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Sarcoidosis 120 99.84 Very High Very High Very High
Apoptosis 14 99.46 Very High Very High Very High
Seronegative Spondarthritis 21 98.56 Very High Very High Very High
Colitis 68 97.70 Very High Very High Very High
Syndrome 57 96.00 Very High Very High Very High
Papillomavirus Infection 18 94.48 High High
INFLAMMATION 384 93.44 High High
Keloid Scars 412 93.08 High High
Arthropathy 2 92.40 High High
Death 11 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-17A immunoreactivity was detected mainly in BAL lymphocytes, and the number of these IL-17A expressing lymphocytes displayed an eight-fold increase, even though not statistically significant.
Negative_regulation (number) of Gene_expression (expressing) of IL-17A in lymphocytes
1) Confidence 0.36 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.28 Pain Relevance 0.10
We found that the relative gene expression of IL-17 in CD4+ T cells was reduced in sarcoidosis patients, statistically significant (although weakly so) in patients with Löfgren's syndrome compared to healthy subjects.
Negative_regulation (reduced) of Gene_expression (expression) of IL-17 in T cells associated with syndrome and sarcoidosis
2) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.67 Pain Relevance 0.07
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Negative_regulation (levels) of Gene_expression (levels) of IL 17
3) Confidence 0.26 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.52 Pain Relevance 0.29
In addition, a recent study reported that methylprednisolone is capable of inhibiting IL-17 production in lymphocytes and lymph node cells [81].
Negative_regulation (inhibiting) of Gene_expression (production) of IL-17 in lymph node
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.21 Pain Relevance 0
Additionally, the IL-17A expression was lower in Löfgren's patients' CD4+ T cells.


Negative_regulation (lower) of Gene_expression (expression) of IL-17A in T cells
5) Confidence 0.20 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.52 Pain Relevance 0
Furthermore, we found a negative correlation between BALF CD4+ T cell IL-17A expression and BALF CD4/CD8 ratio in sarcoidosis, suggesting that the alveolitis seen in patients is associated with an influx of CD4 T cells with on average merely little production of IL-17.
Negative_regulation (correlation) of Gene_expression (expression) of IL-17A in T cell associated with sarcoidosis
6) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.03 Pain Relevance 0.03
Our results indicated that IL-17-induced hTERT and Oct-4 expression was abolished by pretreatment with neutralizing antibody for either IL-17, or IL-6, or both (Figure 5D).
Negative_regulation (abolished) of Gene_expression (expression) of IL-17-induced
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.07 Pain Relevance 0
However, the expression of IL-17 was undetectable in both KPCs and SKPs (data not shown).
Negative_regulation (undetectable) of Gene_expression (expression) of IL-17
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.61 Pain Relevance 0.14
The CD25brightCD4+ T cells suppressed the production of both type 1 and 2 cytokines including interleukin-17, as well as proliferation, independently of diagnosis.
Negative_regulation (suppressed) of Gene_expression (production) of interleukin-17 in T cells associated with cytokine
9) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC464877 Disease Relevance 0.61 Pain Relevance 0.27
Interestingly, prednisone reduced p-STAT3 levels, and recent data suggest that steroid treatment causes reductions in IL-17 production [64].
Negative_regulation (reductions) of Gene_expression (production) of IL-17
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.38 Pain Relevance 0.69
In addition, a recent study reported that methylprednisolone is capable of inhibiting IL-17 production in lymphocytes and lymph node cells [81].
Negative_regulation (inhibiting) of in lymphocytes Gene_expression (production) of IL-17 in lymph node
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.21 Pain Relevance 0
secretion in the absence of detectable IL-4 or IL-17 production.
Negative_regulation (absence) of Gene_expression (production) of IL-17
12) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.29 Pain Relevance 0.10
Moreover, the protective effects of HO-1 in experimental colitis are replicated by administration of hemin, which markedly reduces programmed cell death of colonic epithelium and attenuates the production of interleukin 17 [82].
Negative_regulation (attenuates) of Gene_expression (production) of interleukin 17 in epithelium associated with colitis and apoptosis
13) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.23 Pain Relevance 0.23

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