INT155015

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.45
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA) plasma membrane (HLA-DOA)
Anatomy Link Frequency
blood 1
lamina 1
T cell 1
HLA-DOA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 8 99.84 Very High Very High Very High
Arthritis 5 99.30 Very High Very High Very High
Pain 4 98.86 Very High Very High Very High
spinal inflammation 118 98.32 Very High Very High Very High
Inflammation 76 96.32 Very High Very High Very High
backache 12 95.28 Very High Very High Very High
cva 2 87.12 High High
spondylitis 12 66.96 Quite High
Osteoarthritis 1 62.72 Quite High
imagery 37 50.08 Quite High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 7 100.00 Very High Very High Very High
Uveitis 1 99.96 Very High Very High Very High
Rheumatoid Arthritis 10 99.84 Very High Very High Very High
Viral Infection 2 99.82 Very High Very High Very High
Arthritis 2 99.30 Very High Very High Very High
Pain 4 98.86 Very High Very High Very High
Celiac Disease 59 98.40 Very High Very High Very High
Low Back Pain 140 98.32 Very High Very High Very High
INFLAMMATION 80 98.22 Very High Very High Very High
Disease 125 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA alloimmunization can be induced by blood transfusions, pregnancies, or transplants.
Positive_regulation (induced) of HLA in blood
1) Confidence 0.23 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.30 Pain Relevance 0.04
Patients were enrolled in the suspected early AS group if they were suffering from inflammatory low back pain for more than three months and for less than two years and if at least one of the following features was present: Rapid and substantial pain relief by non-steroidal antiinflammatory drugs, alternating buttock pain, peripheral arthritis, enthesitis, dactylitis, uveitis, HLA B27 status positive, elevated acute phase reactants, family history of AS.
Positive_regulation (elevated) of HLA associated with low back pain, pain, spinal inflammation, backache, seronegative spondarthritis, inflammation, uveitis and arthritis
2) Confidence 0.17 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1810253 Disease Relevance 2.05 Pain Relevance 1.55
During viral infection soluble HLA levels, involved in regulating the immune response, have also been shown to be increased in RA patients, the level of which is dependent on HLA allele present [74, 75].
Positive_regulation (increased) of HLA associated with viral infection and rheumatoid arthritis
3) Confidence 0.05 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.98 Pain Relevance 0.05
Levels were higher in HLA B-27 negative patients (p = 0.02).
Positive_regulation (higher) of HLA
4) Confidence 0.04 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.28
We hypothesise that although we could not detect a response against all epitopes in all HLA class I matched patients even for 100% conserved epitopes, immunising with the epitopes will lead to CD8+ T cell activation in all HLA class I matched individuals.
Positive_regulation (activation) of HLA in T cell
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.22 Pain Relevance 0
The MHC class II products HLA DR and DP are upregulated in the apical epithelium during active celiac sprue, but expression of the disease-associated HLA DQ products is restricted to the lamina propria [120].
Positive_regulation (upregulated) of HLA in lamina associated with celiac disease and disease
6) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.38 Pain Relevance 0

General Comments

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