INT15502

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Context Info
Confidence 0.19
First Reported 1988
Last Reported 2005
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.29
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IAS 3
smooth muscle 1
nerve 1
asp1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 7 99.84 Very High Very High Very High
agonist 1 99.84 Very High Very High Very High
antagonist 3 98.88 Very High Very High Very High
conotoxin 1 96.64 Very High Very High Very High
Kinase C inhibitor 1 96.44 Very High Very High Very High
Neuronal nitric oxide synthase 2 92.40 High High
Neurotransmitter 1 90.32 High High
guanethidine 1 86.80 High High
cva 23 84.52 Quite High
imagery 20 76.96 Quite High
Disease Link Frequency Relevance Heat
Cerebral Aneurysm 129 100.00 Very High Very High Very High
Disease 21 100.00 Very High Very High Very High
Rupture 13 100.00 Very High Very High Very High
Aneurism 15 96.04 Very High Very High Very High
Cv General 4 Under Development 21 84.52 Quite High
Death 11 5.00 Very Low Very Low Very Low
Nicotine Addiction 7 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings revealed that normal IAS is pharmacologically innervated by alpha-adrenergic excitatory nerve, beta-adrenergic inhibitory nerve and non-adrenergic, non-cholinergic inhibitory nerve and suggested that IAS in Hirschsprung's disease is also affected by alpha-adrenergic excitatory nerve but inhibitory neural control is absent.
Regulation (affected) of IAS in nerve associated with disease
1) Confidence 0.19 Published 1990 Journal Nippon Heikatsukin Gakkai Zasshi Section Abstract Doc Link 2102500 Disease Relevance 0.41 Pain Relevance 0.08
Responses of isolated muscle strips from the rat and the dog internal anal sphincter (IAS) to drugs and electrical field stimulation (EFS) were investigated in vitro for the purpose of clarifying a manner of neural control of IAS.
Regulation (control) of IAS in internal anal sphincter
2) Confidence 0.19 Published 1990 Journal Nippon Heikatsukin Gakkai Zasshi Section Abstract Doc Link 2102500 Disease Relevance 0.22 Pain Relevance 0.06
D-Arginine on the other hand, at the same concentration had no effect on L-NNA-suppressed IAS relaxation.
Neg (no) Regulation (effect) of IAS in IAS
3) Confidence 0.13 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1733256 Disease Relevance 0 Pain Relevance 0.12
The inhibitory effect of the agonists on the IAS smooth muscle was not modified by tetrodotoxin (TTX), a neurotoxin.
Neg (not) Regulation (modified) of IAS in smooth muscle associated with tetrodotoxin and agonist
4) Confidence 0.08 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2903675 Disease Relevance 0 Pain Relevance 0.38
Prior studies indicate that genetic factors are important in the formation and rupture of IAs.
Regulation (important) of IAs associated with cerebral aneurysm and rupture
5) Confidence 0.07 Published 2005 Journal BMC Med Genet Section Abstract Doc Link PMC1097731 Disease Relevance 1.66 Pain Relevance 0.12
Endothelin-induced contraction of the IAS, on the other hand, was not affected by any of the neurohumoral antagonists but was significantly inhibited by the selective protein kinase C inhibitor H-7 or the calmodulin inhibitor W-13.
Neg (not) Regulation (affected) of IAS in IAS associated with antagonist and kinase c inhibitor
6) Confidence 0.04 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862776 Disease Relevance 0 Pain Relevance 0.44

General Comments

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