INT155033

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 9.45
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Phlda2)
Anatomy Link Frequency
retina 4
IPL 3
dendrites 2
GCL 2
INL 2
Phlda2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 48 93.60 High High
ischemia 30 87.00 High High
Glutamate 21 69.24 Quite High
Central nervous system 6 69.08 Quite High
agonist 6 62.72 Quite High
Inflammation 15 61.20 Quite High
nMDA receptor antagonist 10 42.60 Quite Low
GABAergic 5 34.00 Quite Low
isoflurane 18 22.08 Low Low
Neurotransmitter 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 316 99.24 Very High Very High Very High
Myopia 88 98.36 Very High Very High Very High
Recurrence 1 98.00 Very High Very High Very High
Cicatrix 1 96.36 Very High Very High Very High
Stress 330 96.08 Very High Very High Very High
Death 173 95.68 Very High Very High Very High
Refractive Errors 68 95.68 Very High Very High Very High
Fabry Disease 5 94.68 High High
Cytomegalovirus Infection 55 93.28 High High
Diabetes Mellitus 254 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These ectopic bipolar synapses were noted to be in close apposition to dendrites of melanopsin ipRGCs near the IPL-INL border [40].
Gene_expression (ipRGCs) of IPL in synapses
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.08 Pain Relevance 0
Since the ganglion cells recorded by Wong and colleagues [10] that were inhibited by L-AP4 were not filled after recording, it is not known whether these ganglion cells had dendrites in the ON or OFF substrata of the IPL.
Gene_expression (substrata) of IPL in dendrites associated with ganglion cysts
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.36 Pain Relevance 0.10
These glutamatergic amacrine cells would then need to send processes to synapse on ipRGC dendrites in the OFF sublayer of the IPL (Fig. 3).
Gene_expression (sublayer) of IPL in dendrites
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.13 Pain Relevance 0
The thicknesses of the IPL, INL and outer nuclear layer (ONL) were measured in the posterior retina at four points, two on either side of the optic nerve that were 200 and 500 ?
Gene_expression (thicknesses) of IPL in retina
4) Confidence 0.25 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.12 Pain Relevance 0
Synaptophysin is a synaptic membrane protein that is abundant in the inner plexiform layer (IPL), where AT1R is also produced [14], and plays a critical role in OPs.
Gene_expression (produced) of IPL in inner plexiform layer
5) Confidence 0.22 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.98 Pain Relevance 0.06
The IPL source can be considered a suitable, effective and safe treatment modality for these cutaneous lesions that typically affect patients with FD, with no need for local anesthesia and with very satisfactory cosmetic results.
Gene_expression (source) of IPL associated with anesthesia and fabry disease
6) Confidence 0.22 Published 2008 Journal J Cosmet Laser Ther Section Abstract Doc Link 18830871 Disease Relevance 1.00 Pain Relevance 0.09
Weak CFP expression was visualized in most ChAT immunoreactive somata in the INL and GCL, and in ChAT immunoreactive processes in the IPL (Figure 8C,F).
Gene_expression (processes) of IPL
7) Confidence 0.21 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.13 Pain Relevance 0
We identify M6a as a gene that is expressed in the embryonic retina and reveal the expression patterns of M6a in the neural processes, including the nerve fiber layer (NFL), inner plexiform layer (IPL), and outer plexiform layer (OPL), of the immature mouse retina.
Gene_expression (expression) of IPL in retina
8) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0.09
Data from three sections (selected randomly from the six sections) were averaged for each eye, and the values obtained were used to evaluate the GCL cell count and the IPL thickness.


Gene_expression (thickness) of IPL in IPL
9) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.42 Pain Relevance 0.06
High-dose tunicamycin significantly decreased both the cell count in GCL and the thickness of IPL.
Gene_expression (thickness) of IPL in GCL
10) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.96 Pain Relevance 0
g/eye, tunicamycin significantly decreased both the cell count in GCL and the IPL thickness (versus the non-treated normal retina; Figure 2).
Gene_expression (thickness) of IPL in eye
11) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.96 Pain Relevance 0
The cells displaying increased fluorescence were ganglion cells (at 12 h after the injection), amacrine cells in IPL (at 24 h), and microglia in GCL (at 72 h).
Gene_expression (amacrine cells) of IPL in GCL associated with ganglion cysts
12) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.31 Pain Relevance 0.04
As shown in Figure 5B, cell loss in GCL and thinning of IPL were observed at 72 h after NMDA injection (versus non-treated control retinas; Figure 5A).
Gene_expression (thinning) of IPL in retinas
13) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.42 Pain Relevance 0
AP expression was observed in the RPE, outer nuclear layer (ONL), inner nuclear layer (INL), OPL, inner plexiform layer (IPL), RGC layer and Müller cells but not the outer and inner segments of the photoreceptor (Figure 1C,E-H).
Gene_expression (expression) of IPL in photoreceptor
14) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.24 Pain Relevance 0
Four weeks after subretinal injection, we observed intense eGFP expression in young and adult groups in the RPE, ONL, INL, OPL, IPL, RGC layers, and Müller cells (Figure 2B,C).
Gene_expression (groups) of IPL in INL
15) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.41 Pain Relevance 0
Upon examination of fluorescence from retinal sections, it appears that both nanoparticles conferred expression in RGCs, but only the TFA-GFP produced EGFP within the IPL, suggesting that these particles were able to transfect some cells within the inner nuclear layer.
Gene_expression (produced) of IPL in inner nuclear layer
16) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.19 Pain Relevance 0
Data from three sections (selected randomly from the six sections) were averaged for each eye, and used to evaluate the cell count in the GCL and the thickness of the IPL.


Gene_expression (thickness) of IPL in IPL
17) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375228 Disease Relevance 0.29 Pain Relevance 0.06
Furthermore, the later increase in the expression of Kir4.1 channels in the IPL of the retina, particularly in sublamina A, during the restriction of ocular growth is likely to be in response to the need for potassium movement out of the extracellular space and around the OFF pathway neurons as a consequence of refractive compensation to plus lens defocus.



Gene_expression (expression) of IPL in retina
18) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.23 Pain Relevance 0
The greatest intensity of AQP4 staining was seen in the NFL; however, the greatest intensity of Kir4.1 immunoreactivity was always present in the IPL (see Figure 3 and Figure 4A).


Gene_expression (present) of IPL
19) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.37 Pain Relevance 0
No significant differences were seen in the level of AQP4 expression in the IPL, suggesting that AQP4 upregulation only occurs at the endfeet of Müller cells at the vitreal border in growing eyes.


Gene_expression (expression) of IPL in eyes
20) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.67 Pain Relevance 0

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