INT155039

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 7.85
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
chondrocytes 6
tendon 2
temporomandibular joint 2
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 135 100.00 Very High Very High Very High
Snapping jaw 6 99.24 Very High Very High Very High
Osteoarthritis 615 99.20 Very High Very High Very High
cytokine 133 97.96 Very High Very High Very High
Inflammation 180 94.80 High High
Pain 103 80.20 Quite High
rheumatoid arthritis 68 76.88 Quite High
Arthritis 28 76.84 Quite High
cINOD 44 74.72 Quite High
depression 1 62.24 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 6 99.24 Very High Very High Very High
Osteoarthritis 605 99.20 Very High Very High Very High
Intervertebral Disk Degeneration 100 98.84 Very High Very High Very High
Knee Osteoarthritis 41 98.48 Very High Very High Very High
Cancer 27 98.40 Very High Very High Very High
Necrosis 24 98.12 Very High Very High Very High
Aging 434 97.92 Very High Very High Very High
Pressure And Volume Under Development 47 95.72 Very High Very High Very High
INFLAMMATION 183 94.80 High High
Injury 46 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of ADAMTS-5 in deformed human temporomandibular joint discs.
Gene_expression (Expression) of ADAMTS-5 in temporomandibular joint associated with snapping jaw
1) Confidence 0.67 Published 2008 Journal Histol. Histopathol. Section Title Doc Link 18830934 Disease Relevance 0.10 Pain Relevance 0.24
Subsequently, the expression of ADAMTS-5 was examined using reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (expression) of ADAMTS-5
2) Confidence 0.67 Published 2008 Journal Histol. Histopathol. Section Body Doc Link 18830934 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To study the expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) in tissue samples of deformed human temporomandibular joint (TMJ) discs and cells obtained from the discs.
Gene_expression (expression) of ADAMTS-5 in temporomandibular joint associated with snapping jaw and metalloproteinase
3) Confidence 0.58 Published 2008 Journal Histol. Histopathol. Section Abstract Doc Link 18830934 Disease Relevance 0.17 Pain Relevance 0.22
No gene expression for p16INK4a, MMP-13, or ADAMTS 5 was observed in directly extracted NP cells from non-degenerate discs, but expression for these genes was seen in NP cells directly extracted from degenerate discs (average: p16INK4a, 1,893 copies/100 ng of cDNA; MMP-13, 9,386 copies/100 ng of cDNA; ADAMTS 5, 21,220 copies/100 ng of cDNA).


Gene_expression (expression) of ADAMTS 5
4) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.30 Pain Relevance 0
Regression analysis and Spearman rank correlation were performed to analyse correlations between p16INK4a and matrix-degrading enzymes (MMP-13 and ADAMTS 5) gene expression.



Spec (analyse) Gene_expression (expression) of ADAMTS 5
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.10 Pain Relevance 0
No gene expression for p16INK4a, MMP-13, or ADAMTS 5 was observed in directly extracted NP cells from non-degenerate discs, but expression for these genes was seen in NP cells directly extracted from degenerate discs (average: p16INK4a, 1,893 copies/100 ng of cDNA; MMP-13, 9,386 copies/100 ng of cDNA; ADAMTS 5, 21,220 copies/100 ng of cDNA).


Gene_expression (expression) of ADAMTS 5
6) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.30 Pain Relevance 0
Aliquots of cells (0.5 × 106 cells) were also taken in duplicate prior to culture (that is, directly extracted cells) and at each passage for analysis of p16INK4a, MMP-13 (matrix metalloproteinase-13), ADAMTS 5 (a disintegrin and metalloprotease with thrombospondin motifs 5), and hTERT (human telomerase reverse transcriptase) gene expression.


Gene_expression (expression) of ADAMTS 5 associated with metalloproteinase
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.06 Pain Relevance 0.05
Here, we demonstrate for the first time that, in cells extracted from human NP tissue, increased levels of p16INK4a were associated with increased gene expression of the degradative enzymes MMP-13 and ADAMTS 5, which is characteristic of disc degeneration [5,39].
Gene_expression (expression) of ADAMTS 5 associated with intervertebral disk degeneration
8) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.45 Pain Relevance 0.07
The combination of all samples investigated demonstrated a significant positive correlation between p16INK4a gene expression and the gene expression for the matrix-degrading enzymes MMP-13 and ADAMTS 5 (P values < 0.05) (Figure 4a, b).


Gene_expression (expression) of ADAMTS 5
9) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.37 Pain Relevance 0
In cells derived from the non-degenerate discs, a slight, nonsignificant decrease in aggrecanase gene expression was observed (Fig. 4c,d).


Gene_expression (expression) of aggrecanase gene
10) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
Aggrecanase (ADAMTS-4 and -5) gene expression was increased in cells derived from the NP of degenerate discs.
Gene_expression (expression) of Aggrecanase
11) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
However, such treatment did result in an increase in the gene expression of the aggrecanase ADAMTS-4 in cells derived from degenerate NP.
Gene_expression (expression) of aggrecanase
12) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.08 Pain Relevance 0
ADAMTS-5 gene expression was not significantly altered by IL-1 treatment.
Gene_expression (expression) of ADAMTS-5
13) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.07 Pain Relevance 0
These findings were confirmed by the experiments in which we demonstrated in human OA chondrocytes that gal-3 stimulated the expression of ADAMTS-5 and MMP-3, the main enzymes involved in proteoglycan degradation in cartilage.
Gene_expression (expression) of ADAMTS-5 in chondrocytes associated with metalloproteinase and osteoarthritis
14) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.48 Pain Relevance 0.21
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
Gene_expression (expression) of aggrecanase in tendon
15) Confidence 0.19 Published 2008 Journal Matrix Biol Section Title Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.20
g/ml stimulated ADAMTS-5 expression in chondrocytes and, at higher concentrations (5 and 10 ?
Gene_expression (expression) of ADAMTS-5 in chondrocytes
16) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.43 Pain Relevance 0.05
Data show that human OA chondrocytes incubated with rh-gal-3 for 24 h increased ADAMTS-5 expression in a biphasic mode.
Gene_expression (expression) of ADAMTS-5 in chondrocytes associated with osteoarthritis
17) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.40 Pain Relevance 0.30
These enzymes belong to the ADAMTS family and were further designated ADAMTS-4 and ADAMTS-5, respectively.
Gene_expression (designated) of ADAMTS-5
18) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.62 Pain Relevance 0.19
Although no true selective inhibitor of aggrecanase has been reported, efforts to discover tumour necrosis factor-?
Neg (no) Gene_expression (selective) of aggrecanase associated with necrosis and cancer
19) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.65 Pain Relevance 0.19
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
Gene_expression (expression) of aggrecanase in tendon
20) Confidence 0.07 Published 2008 Journal Matrix Biol Section Title Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.20

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