INT155041

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.25
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
cartilage 1
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 31 99.10 Very High Very High Very High
Inflammation 37 98.90 Very High Very High Very High
Inflammatory response 3 97.76 Very High Very High Very High
metalloproteinase 34 84.36 Quite High
Pain 28 79.68 Quite High
adenocard 2 63.28 Quite High
agonist 8 61.76 Quite High
Mechanotransduction 1 55.48 Quite High
Snapping jaw 2 50.00 Quite Low
Osteoarthritis 32 30.12 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 98.90 Very High Very High Very High
Targeted Disruption 2 91.12 High High
Osteoporosis 6 86.96 High High
Pain 12 79.68 Quite High
Pressure And Volume Under Development 17 79.32 Quite High
Arthritis 10 78.92 Quite High
Injury 8 75.32 Quite High
Temporomandibular Joint Syndrome 2 58.64 Quite High
Tendinopathy 10 54.48 Quite High
Hyperplasia 1 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discs extracted from cases with ID and OA presented positive reactions for ADAMTS-5.
Positive_regulation (reactions) of ADAMTS-5
1) Confidence 0.44 Published 2008 Journal Histol. Histopathol. Section Body Doc Link 18830934 Disease Relevance 0.06 Pain Relevance 0
Studies using explant and cell cultures from other tissues have shown increased aggrecanase activity under conditions where ADAMTS mRNA and/or protein levels are not altered (Caterson et al., 2000; Flannery et al., 2000; Yaminishi et al., 2002; Pratta et al., 2003; Patwari et al., 2005), indicating that both the translation of the mRNA and the processing of the ADAMTS proenzymes are subject to regulation.
Positive_regulation (increased) of aggrecanase
2) Confidence 0.22 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.05 Pain Relevance 0.11
Aggrecanase (ADAMTS-4 and -5) gene expression was increased in cells derived from the NP of degenerate discs.
Positive_regulation (increased) of Aggrecanase
3) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
Our RT-PCR results demonstrated that the expression levels of mRNA for FGF2 and its cognate receptor FGFR1, as well as those for matrix-degrading enzymes MMP-13 and ADAMTS5 (also known as aggrecanase 2), are highly upregulated in degenerative human NP cells.
Positive_regulation (upregulated) of aggrecanase 2
4) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0 Pain Relevance 0
On the other hand, we so far have no explanation for the rebound phenomenon observed for ADAMTS-5 stimulation with 1 ?
Positive_regulation (stimulation) of ADAMTS-5
5) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.18 Pain Relevance 0.15
Thus, while arthroscopic procedures make surgery less invasive, the inflammatory response at the joint remains and the release of pro-inflammatory cytokines in the synovial fluid is associated with an increase in the aggrecanase activities that lead to a degradation of the cartilage matrix, and also inhibit proteoglycan synthesis [11, 15, 18].
Positive_regulation (increase) of aggrecanase in cartilage associated with inflammatory response, inflammation and cytokine
6) Confidence 0.04 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2413121 Disease Relevance 0.95 Pain Relevance 0.56

General Comments

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