INT155045

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.04
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
T cells 4
cheek 3
rostrum 1
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 231 100.00 Very High Very High Very High
Kinase C 1 76.24 Quite High
Neuropeptide 8 50.00 Quite Low
Inflammation 22 46.08 Quite Low
agonist 12 41.28 Quite Low
Arthritis 2 32.20 Quite Low
tolerance 4 22.04 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 42 87.44 High High
Skin Cancer 204 81.08 Quite High
Cancer 110 80.32 Quite High
Stress 22 65.56 Quite High
INFLAMMATION 24 46.08 Quite Low
Stomach Cancer 2 44.96 Quite Low
Pressure And Volume Under Development 6 35.20 Quite Low
Colitis 4 34.88 Quite Low
Uveitis 2 33.16 Quite Low
Arthritis 2 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous results implicated a single derived amino acid change in the melanocortin-1 receptor (Mc1r) as a major contributor to pigment pattern in the Gulf Coast beach mice; despite phenotypic similarities, the derived Mc1r allele was not found in the Atlantic coast beach mouse populations.
Negative_regulation (derived) of Gene_expression (allele) of Mc1r associated with melanocortin 1 receptor
1) Confidence 0.43 Published 2009 Journal Mol. Biol. Evol. Section Abstract Doc Link 18832078 Disease Relevance 0 Pain Relevance 0.53
Similarly, Bop1, another negative regulator of the cell cycle, was repressed by UVB in Mc1re/Mc1re animals but not in Mc1r+/Mc1r+ animals, while Mark3 and Cdc2l1, both positive cell cycle regulators, were induced by UVB in Mc1re/Mc1re animals but not in Mc1r+/Mc1r+ animals.
Negative_regulation (repressed) of Neg (not) Gene_expression (animals) of Mc1r
2) Confidence 0.42 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.30 Pain Relevance 0.08
Similarly, Bop1, another negative regulator of the cell cycle, was repressed by UVB in Mc1re/Mc1re animals but not in Mc1r+/Mc1r+ animals, while Mark3 and Cdc2l1, both positive cell cycle regulators, were induced by UVB in Mc1re/Mc1re animals but not in Mc1r+/Mc1r+ animals.
Negative_regulation (repressed) of Neg (not) Gene_expression (animals) of Mc1r
3) Confidence 0.42 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.30 Pain Relevance 0.08
We also compared levels of Mc1r expression between the three taxa for four body regions (rostrum, cheek, eyebrow, and earbase) that show large differences in pigmentation between beach and mainland mice.
Negative_regulation (levels) of Gene_expression (expression) of Mc1r in cheek associated with melanocortin 1 receptor
4) Confidence 0.42 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.67
Through which signaling pathway does ASIP/MC1R induce biological effects, if not through reduced cAMP?
Negative_regulation (does) of Neg (not) Gene_expression (induce) of MC1R associated with melanocortin 1 receptor
5) Confidence 0.40 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.08 Pain Relevance 0.30
Hence, our results are in accordance with the earlier findings by Neumann-Andersen et al. showing the expression of MC-1R on natural killer cells and cytotoxic CD8+ T cells whereas only 1% of CD4+ T cells could be stained for MC-1R [57].
Negative_regulation (showing) of Gene_expression (expression) of MC-1R in T cells
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0 Pain Relevance 0
However, only a feeble expression of MC-1R was detectable in naive CD4+ T cells and moreover, no up-regulation was found after stimulation with ?
Negative_regulation (detectable) of Gene_expression (expression) of MC-1R in T cells
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.36 Pain Relevance 0
We also compared levels of Mc1r expression between the three taxa for four body regions (rostrum, cheek, eyebrow, and earbase) that show large differences in pigmentation between beach and mainland mice.
Negative_regulation (levels) of in rostrum Gene_expression (expression) of Mc1r in cheek associated with melanocortin 1 receptor
8) Confidence 0.14 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.67

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox