INT15505

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Context Info
Confidence 0.24
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.50
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 1
CSF 1
caudate-putamen 1
nt (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 7 100.00 Very High Very High Very High
Cholecystokinin 7 100.00 Very High Very High Very High
depression 4 99.28 Very High Very High Very High
Dopamine 2 98.56 Very High Very High Very High
Nucleus accumbens 7 98.30 Very High Very High Very High
Dismenorea 2 97.96 Very High Very High Very High
Pain 1 97.68 Very High Very High Very High
Morphine 3 97.28 Very High Very High Very High
opiate 3 94.60 High High
tetrodotoxin 2 80.96 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 4 99.56 Very High Very High Very High
Depression 4 99.28 Very High Very High Very High
Appetite Loss 1 98.80 Very High Very High Very High
Death 7 98.76 Very High Very High Very High
Eating Disorder 3 98.44 Very High Very High Very High
Reprotox - General 1 2 97.96 Very High Very High Very High
Pain 1 97.68 Very High Very High Very High
Obesity 20 96.84 Very High Very High Very High
Pick Disease Of The Brain 1 84.48 Quite High
Disorder Of Lipid Metabolism 16 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Slices of caudate-putamen (CP) and nucleus accumbens (NA) prepared from Long-Sleep (LS) and Short-Sleep (SS) mice were used to determine the effects of neurotensin (NT) and ethanol on K(+)-stimulated 3H-dopamine (3H-DA) release and to test the hypothesis that ethanol acts, in part, via NT receptor-mediated processes.
Spec (determine) Regulation (effects) of NT in caudate-putamen associated with nucleus accumbens and dopamine
1) Confidence 0.24 Published 1992 Journal Alcohol Section Abstract Doc Link 1733422 Disease Relevance 0 Pain Relevance 0.32
The investigation concerned the effects of neurotensin (NT) on the mechanical activity of segments of guinea-pig proximal colon.
Regulation (effects) of NT in colon
2) Confidence 0.18 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7297599 Disease Relevance 0 Pain Relevance 0.08
Alterations in the NT levels may underlie several medical conditions including pain, depression and obesity.
Regulation (Alterations) of NT associated with pain, depression and obesity
3) Confidence 0.06 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.48 Pain Relevance 0.18
These effects have been reported to be mediated via a hypothalamic mechanism, which modulates the secretion of releasing, release inhibiting factors or other neuroactive peptides such as SP, CCK and NT.
Regulation (modulates) of NT associated with cholecystokinin and substance p
4) Confidence 0.03 Published 1982 Journal Brain Res. Section Abstract Doc Link 6184121 Disease Relevance 0 Pain Relevance 1.04
NT concentrations were unaltered in patients with depression, anorexia/bulimia, or premenstrual syndrome, and no rostral-caudal gradient for NT in CSF was evident.
Regulation (unaltered) of NT in CSF associated with appetite loss, depression, dismenorea and eating disorder
5) Confidence 0.01 Published 1989 Journal J Neuropsychiatry Clin Neurosci Section Abstract Doc Link 2577718 Disease Relevance 0.94 Pain Relevance 0.26
Serum NT values were determined by an ELISA kit (HyCult Biotechnology Pantec, Turin, Italy; inter-assay precision 3.3%; intra-assay CV 5%).
Regulation (values) of NT
6) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.08 Pain Relevance 0
Apart from the large differences recorded for vitamin C and resistin concentrations, only NT and reduced glutathione variations were affected by the antioxidant treatment.
Regulation (affected) of NT
7) Confidence 0.01 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0 Pain Relevance 0

General Comments

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