INT155057

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.91
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Akp3)
Anatomy Link Frequency
brain 1
Akp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 7 98.12 Very High Very High Very High
dexamethasone 43 97.54 Very High Very High Very High
anesthesia 1 80.24 Quite High
ischemia 2 75.00 Quite High
cva 1 52.48 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 117 100.00 Very High Very High Very High
Diabetes Mellitus 9 92.68 High High
Osteoporosis 27 85.28 High High
Neurodegenerative Disease 3 75.00 Quite High
Cv General 4 Under Development 1 75.00 Quite High
Middle Cerebral Artery Infarction 1 73.92 Quite High
Brain Hemorrhage 1 66.76 Quite High
Cardiovascular Disease 2 54.40 Quite High
Cv General 3 Under Development 1 52.48 Quite High
Death 13 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analogous to, although different from the observed effects of Dex exposure, mitogen withdrawal also did not decrease expression of any prosurvival genes, and instead resulted in increased transcription of the anti-apoptotic proteins Bcl-2, IAP-1, IAP-2, FLIPLong and FLIPShort.
Transcription (transcription) of IAP-2 associated with apoptosis, withdrawal and dexamethasone
1) Confidence 0.11 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.52 Pain Relevance 0.28
The G-CSF also increased the expression of pSTAT3, Bcl-2, and cIAP2 proteins as well as Bcl-2 mRNA, but inhibited Bax protein expression in the brain.
Transcription (expression) of cIAP2 in brain
2) Confidence 0.01 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.39 Pain Relevance 0.18

General Comments

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