INT15508

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Context Info
Confidence 0.36
First Reported 1981
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 3.40
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
muscle 1
nerve 1
brain 1
nt (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 99.80 Very High Very High Very High
Nucleus accumbens 7 99.38 Very High Very High Very High
guanethidine 1 99.00 Very High Very High Very High
tetrodotoxin 3 98.28 Very High Very High Very High
Bioavailability 1 97.56 Very High Very High Very High
agonist 1 96.94 Very High Very High Very High
Neurotransmitter 2 95.28 Very High Very High Very High
Analgesic 5 92.00 High High
Ventral tegmentum 1 89.92 High High
Dopamine 3 87.40 High High
Disease Link Frequency Relevance Heat
Pain 8 99.80 Very High Very High Very High
Syndrome 3 99.28 Very High Very High Very High
Diabetes Mellitus 18 98.52 Very High Very High Very High
Muscular Spasm 6 98.24 Very High Very High Very High
Stress 36 97.80 Very High Very High Very High
Disorder Of Lipid Metabolism 12 97.72 Very High Very High Very High
Injury 3 94.04 High High
Muscle Hypertonia 1 92.80 High High
Neurological Disease 1 90.68 High High
Nicotine Addiction 9 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relaxant effect of NT was unaffected by TTX (0.2 microM) and guanethidine (2 microM), but markedly reduced or abolished by apamin (67 nM). 3.
Neg (unaffected) Negative_regulation (unaffected) of NT associated with guanethidine
1) Confidence 0.36 Published 1994 Journal J Auton Pharmacol Section Abstract Doc Link 7929476 Disease Relevance 0 Pain Relevance 0.15
The absence of an NT effect in NA slices was not due to a rapid desensitization of NT receptors but the data were consistent with the absence of presynaptic NT receptors on dopaminergic terminals in the NA.
Negative_regulation (desensitization) of NT associated with nucleus accumbens
2) Confidence 0.26 Published 1992 Journal Alcohol Section Abstract Doc Link 1733422 Disease Relevance 0 Pain Relevance 0.44
Concentration-response curves for the inhibitory effect of NT, adrenaline and ATP indicated that NT (IC50 0.32 nM) was 100 times more potent than adrenaline (IC50 nM) and 50 000 times more potent than ATP (IC50 16 microM).
Negative_regulation (effect) of NT
3) Confidence 0.17 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7297599 Disease Relevance 0 Pain Relevance 0.09
In summary, SR 142948A retains the properties of the lead compound SR 48692 (no intrinsic agonist activity, oral bioavailability, long duration of action and good brain access), reveals a wider spectrum of activity than SR 48692 (probably due to the inhibition of NT receptor subtypes) and represents an additional tool for further exploration of the therapeutic potential of this class of compounds.
Negative_regulation (inhibition) of NT receptor in brain associated with agonist and bioavailability
4) Confidence 0.08 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023294 Disease Relevance 0.08 Pain Relevance 0.31
This treatment was also associated with other changes in oxidation-related variables (reduction of NT levels and incremental increase of reduced glutathione).
Negative_regulation (reduction) of NT
5) Confidence 0.03 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.34 Pain Relevance 0.15
Besides the reduction in muscle tone BoNT tends to reduce pain in pain syndromes associated with muscle spasm.
Negative_regulation (reduction) of BoNT in muscle associated with pain, syndrome and muscular spasm
6) Confidence 0.03 Published 2004 Journal J. Neurol. Section Abstract Doc Link 14991339 Disease Relevance 1.18 Pain Relevance 0.76
In the experimental group, NT levels were significantly reduced after the supplementation, while a very slight increase was evident in the control group.
Negative_regulation (reduced) of NT
7) Confidence 0.02 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.68 Pain Relevance 0.06
In June–July 2005, a total of 80 eligible participants were enrolled and submitted in the morning, at fasting, to measurements of weight, waist circumference, and blood pressure, and to determinations of serum glucose, total cholesterol, HDL cholesterol, triglyceride, insulin, high-sensitivity CRP (hs-CRP), vitamin A, vitamin C, vitamin E, oxidized and reduced glutathione, NT, and resistin levels.
Negative_regulation (reduced) of NT in blood associated with disorder of lipid metabolism
8) Confidence 0.02 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.35 Pain Relevance 0.03
The various serotypes of botulinum toxin (BoNT) exert their action by inhibiting the exocytosis of acetylcholine (ACh) on cholinergic nerve endings.
Negative_regulation (inhibiting) of BoNT in nerve
9) Confidence 0.01 Published 2004 Journal J. Neurol. Section Abstract Doc Link 14991335 Disease Relevance 0.52 Pain Relevance 0.13
On the other hand, Nt and LPH levels reached a peak at 60 min and these levels gradually decreased up to 120 min.
Negative_regulation (decreased) of Nt
10) Confidence 0.00 Published 1986 Journal Endocrinol. Jpn. Section Abstract Doc Link 3034555 Disease Relevance 0.24 Pain Relevance 0.15

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