INT155081

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.32
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kiss1) vesicle-mediated transport (Kiss1) extracellular region (Kiss1)
cytoplasm (Kiss1)
Anatomy Link Frequency
hippocampus 2
neuronal 1
dorsal root ganglion 1
Kiss1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 6 99.68 Very High Very High Very High
dorsal root ganglion 4 92.52 High High
tetrodotoxin 3 83.40 Quite High
spinal dorsal horn 1 68.64 Quite High
IPN 1 53.44 Quite High
abdominal pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 61 95.56 Very High Very High Very High
Ganglion Cysts 4 92.04 High High
Convulsion 6 89.68 High High
Disease 24 83.80 Quite High
Cancer 34 55.04 Quite High
Carcinoma 26 25.00 Low Low
Abdominal Pain 1 25.00 Low Low
Death 5 5.00 Very Low Very Low Very Low
Endometroid Carcinoma 2 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, KiSS1 expression is upregulated by neuronal activity and activation of GPR54 by kisspeptin may in turn contribute to sustain basal BDNF levels required for hippocampal function.
Gene_expression (expression) of KiSS1 in neuronal
1) Confidence 0.78 Published 2008 Journal Brain Res. Section Abstract Doc Link 18834866 Disease Relevance 0.14 Pain Relevance 0.15
Factors that regulate KiSS1 gene expression in the hippocampus.
Gene_expression (expression) of KiSS1 in hippocampus associated with hippocampus
2) Confidence 0.78 Published 2008 Journal Brain Res. Section Title Doc Link 18834866 Disease Relevance 0.14 Pain Relevance 0.15
The present study examined how expression of KiSS1 and GPR54 is regulated in rat hippocampus, using in vivo and in vitro preparations.
Gene_expression (expression) of KiSS1 in hippocampus associated with hippocampus
3) Confidence 0.78 Published 2008 Journal Brain Res. Section Abstract Doc Link 18834866 Disease Relevance 0.17 Pain Relevance 0.14
In the present study, we gave the first report that kisspeptin and GPR54 were expressed in the small- to large-sized neurons, and co-localized with Bandeiraea simplicifolia isolectin B4 (IB4), calcitonin-gene-related peptide (CGRP) and neurofilament 200 (NF200) in the L4/5 dorsal root ganglion (DRG) of naïve rats, detected by the double immunofluorescent staining.
Gene_expression (expressed) of kisspeptin in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.58 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19111911 Disease Relevance 0.33 Pain Relevance 0.25
In this retrospective study we assessed the protein expression of 21 candidate tissue-based biomarkers (CA125, CRABP-II, EpCam, ER, F-Spondin, HE4, IGF2, K-Cadherin, Ki-67, KISS1, Matriptase, Mesothelin, MIF, MMP7, p21, p53, PAX8, PR, SLPI, TROP2, WT1) in a population-based cohort of 500 ovarian carcinomas that was collected over the period from 1984 to 2000.
Gene_expression (expression) of KISS1 associated with ovarian cancer
5) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2592352 Disease Relevance 0.54 Pain Relevance 0

General Comments

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